INT237341

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.16
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Mtm1) endosome (Mtm1) transport (Mtm1)
plasma membrane (Mtm1) cytoplasm (Mtm1)
Anatomy Link Frequency
muscle 2
skeletal muscle 1
myotubes 1
I band 1
tubules 1
Mtm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 87.08 High High
Sciatic nerve 7 50.48 Quite High
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
sodium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 87.08 High High
Muscle Weakness 28 87.04 High High
Cytomegalovirus Infection 91 86.76 High High
Disease 35 81.84 Quite High
Charcot Marie Tooth Disease 28 78.48 Quite High
Demyelinating Disease 14 77.92 Quite High
Congenital Structural Myopathies 119 75.00 Quite High
Muscle Disease 35 58.12 Quite High
Death 14 56.44 Quite High
Muscle Hypotonia 7 25.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that a substantial proportion of myotubularin associates with the sarcolemma and I band, including triads.
myotubularin Binding (associates) of in I band
1) Confidence 0.48 Published 2008 Journal Human Molecular Genetics Section Abstract Doc Link PMC2441725 Disease Relevance 0.26 Pain Relevance 0
Given this propensity to associate with the plasma membrane, we believe that triadic myotubularin may bind at T-tubules which are the plasma membrane invaginations that, together with terminal cisternae of sarcoplasmic reticulum, form the triads where excitation–contraction coupling occurs (34).
myotubularin Binding (bind) of in tubules
2) Confidence 0.42 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0
To further investigate the precise location within the I-band, we performed immunoelectron microscopy on muscle sections and found that myotubularin associates with the triad, a specialized structure where the excitation–contraction coupling takes place (Fig. 5C).
myotubularin Binding (associates) of in muscle
3) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.09 Pain Relevance 0.03
In particular, the MTM1 protein appears cytoplasmic in various cell lines and has been found associated with endosomes (20,23).
MTM1 Binding (associated) of
4) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.42 Pain Relevance 0
These results contrast with previous studies showing that endogenous myotubularin is mainly cytoplasmic in C2C12 myotubes (20) and suggest that it associates with sarcolemma and triads only upon myofiber maturation.
myotubularin Binding (associates) of in myotubes
5) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0
Myotubularin replacement restores the contractile force of Mtm1 mutant muscle
Myotubularin Binding (replacement) of in muscle
6) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.40 Pain Relevance 0.04
Our results indicate that when highly overexpressed in skeletal muscle, myotubularin alters membrane homeostasis leading to the formation of packed membrane assemblies close to the sarcolemma and of vacuoles that are positive for dystrophin, caveolin-3 and DHPR?
myotubularin Binding (alters) of in skeletal muscle
7) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0

General Comments

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