INT237346

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.71
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Mtm1) endosome (Mtm1) transport (Mtm1)
plasma membrane (Mtm1) cytoplasm (Mtm1)
Anatomy Link Frequency
skeletal muscle 4
muscle 2
muscle fibers 1
Mtm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 8 90.80 High High
Inflammation 16 66.40 Quite High
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
sodium channel 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Structural Myopathies 136 87.44 High High
Cytomegalovirus Infection 104 68.56 Quite High
INFLAMMATION 16 66.40 Quite High
Charcot Marie Tooth Disease 32 66.12 Quite High
Demyelinating Disease 16 65.56 Quite High
Disease 40 62.32 Quite High
Death 16 44.08 Quite Low
Muscle Weakness 32 36.32 Quite Low
Muscle Hypotonia 8 12.72 Low Low
Muscle Disease 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcellular fractionation studies provided further confirmation that the localization of overexpressed myotubularin in muscle likely corresponds to that of the endogenous protein as they revealed a similar pattern of distribution.
Localization (localization) of myotubularin in muscle
1) Confidence 0.80 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0
No data have been reported up to date on the subcellular localization and specific function of myotubularin in muscle fibers.
Localization (localization) of myotubularin in muscle fibers
2) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.37 Pain Relevance 0
Apparently low levels of myotubularin expression in skeletal muscle had previously precluded determination of myotubularin’s subcellular localization in this tissue.
Localization (localization) of myotubularin in skeletal muscle
3) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.22 Pain Relevance 0.03
The specific function of myotubularin and its subcellular localization in skeletal muscle are presently unknown.
Localization (localization) of myotubularin in skeletal muscle
4) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0
The sensitivity of this novel antibody in skeletal muscle is rather low by immunohistochemistry but was sufficient to detect endogenous myotubularin on semithin sections (Fig. 5B).
Localization (detect) of myotubularin in skeletal muscle
5) Confidence 0.70 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0.05
Confocal microscopic examination of AAV transduced muscle overexpressing myotubularin revealed considerably stronger signal at the triads and specific localization at the sarcolemma as well.
Localization (localization) of myotubularin in muscle
6) Confidence 0.65 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.06 Pain Relevance 0
We found that, in both conditions, myotubularin is distributed in the cytosolic S3 fraction, containing glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and in the membrane P3 fraction, containing caveolin 3 (which is associated with sarcolemmal caveolae) (Fig. 5D).
Localization (distributed) of myotubularin
7) Confidence 0.65 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.06 Pain Relevance 0
Localization of myotubularin in skeletal muscle
Localization (Localization) of myotubularin in skeletal muscle
8) Confidence 0.65 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0 Pain Relevance 0

General Comments

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