INT237377

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 3.64
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
CD86 21
B cells 8
salivary gland 2
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 83 99.78 Very High Very High Very High
Multiple sclerosis 37 96.04 Very High Very High Very High
imagery 47 91.44 High High
agonist 66 90.88 High High
cytokine 106 90.52 High High
Central nervous system 23 85.08 High High
Deep tissue 2 81.44 Quite High
Inflammation 56 77.96 Quite High
abatacept 10 71.84 Quite High
Potency 1 67.36 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 83 99.78 Very High Very High Very High
Infection 122 98.70 Very High Very High Very High
Cancer 189 97.10 Very High Very High Very High
Multiple Sclerosis 71 96.04 Very High Very High Very High
Neurodegenerative Disease 6 95.48 Very High Very High Very High
Disease 48 93.28 High High
Targeted Disruption 10 87.24 High High
Viral Infection 11 86.80 High High
Systemic Lupus Erythematosus 46 84.40 Quite High
Apoptosis 38 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin C did not affect the expressions of CD80 and CD86 in activated B cells
Neg (not) Regulation (affect) of Gene_expression (expressions) of CD86 in B cells
1) Confidence 0.47 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Pretreatment with vitamin C in the safe range did not affect either proliferation of cultured B cells or the expression of CD80 and CD86 in those cells.
Neg (not) Regulation (affect) of Gene_expression (expression) of CD86 in CD86
2) Confidence 0.47 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.08 Pain Relevance 0
Alteration of CD86 expression may function to promote salivary gland molecule driven Th2 responses, potentially increasing pathogen transmission.
Regulation (Alteration) of Gene_expression (expression) of CD86 in salivary gland
3) Confidence 0.38 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.08 Pain Relevance 0
More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.
Regulation (upregulation) of Gene_expression (expression) of CD86 in CD86 associated with cancer
4) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.85 Pain Relevance 0.07
To summarize, vitamin C did not affect proliferation, or CD80 and CD86 expression in cultures of activated B cells.
Neg (not) Regulation (affect) of Gene_expression (expression) of CD86 in B cells
5) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.11
Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5).
Neg (not) Regulation (affect) of Gene_expression (expression) of CD86 in CD86
6) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Pretreatment with vitamin C in the safe range did not affect either proliferation of cultured B cells or the expression of CD80 and CD86 in those cells.
Neg (not) Regulation (affect) of Gene_expression (expression) of CD86 in CD86
7) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.08 Pain Relevance 0
To summarize, vitamin C did not affect proliferation, or CD80 and CD86 expression in cultures of activated B cells.
Regulation (proliferation) of Gene_expression (expression) of CD86 in B cells
8) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.08
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of Gene_expression (expression) of CD86 in B cells
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
The results suggested that E2 could enhance the PDCs' activation and maturation by changing the CD40 and CD86 expression.


Regulation (changing) of Gene_expression (expression) of CD86 in CD86
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.17 Pain Relevance 0
Further studies could examine whether the bioactive factor(s) in SGE act synergistically with IL-4 via ERK1/2 pathways to regulate CD86 expression and subsequent Th2 polarization.
Spec (whether) Regulation (regulate) of Gene_expression (expression) of CD86 in CD86
11) Confidence 0.28 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.07 Pain Relevance 0
In an experimental model of JEV infection, we have observed that the Nestin positive cells express and up-regulate the expression of costimulatory molecules, CD40, CD80 and CD86 on their surface.
Regulation (regulate) of Gene_expression (expression) of CD86 in CD86 associated with infection
12) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.49 Pain Relevance 0.09
Our data demonstrate the existence of important alterations in the phenotype of peripheral B cells from RA patients, involving the expression of the co-stimulatory molecule CD86 and the inhibitory receptor Fc?
Regulation (involving) of Gene_expression (expression) of CD86 in CD86 associated with rheumatoid arthritis
13) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.36 Pain Relevance 0.18
It is well known that the levels of CD80 and CD86 vary with the degree of activation of the APC.
Regulation (vary) of Gene_expression (levels) of CD86 in CD86
14) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.83 Pain Relevance 0.43
Regulation (i. Cont) of Gene_expression (le express) of CD86 in CD86
15) Confidence 0.13 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2780913 Disease Relevance 0 Pain Relevance 0
but had no effect on the expression of CD80 and CD86 costimulatory molecules.
Neg (no) Regulation (effect) of Gene_expression (expression) of CD86 in CD86
16) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.54 Pain Relevance 0.43

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