INT237379

Context Info Confidence 0.05 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.71 Pain Relevance 0.82

extracellular space (Ebi3, Il27) extracellular region (Ebi3, Il27)

Ebi3 (Mus musculus) Il27 (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 2 98.16 agonist 66 96.24 Inflammation 27 95.68 rheumatoid arthritis 2 83.44 cytokine 90 82.88 Multiple sclerosis 32 80.88 Central nervous system 21 32.08 antagonist 5 7.68 chemokine 12 5.00 tolerance 6 5.00

Disease Link Frequency Relevance Heat Epstein-barr Virus 3 100.00 Experimental Arthritis 2 98.16 Disease 23 96.24 INFLAMMATION 28 95.68 Autoimmune Disease 2 92.64 Infection 76 91.76 Multiple Sclerosis 62 86.96 Rheumatoid Arthritis 2 83.44 Arthritis 2 79.44 Inflammatory Bowel Disease 4 47.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

of p28 in association with EBV-induced molecule 3 (EBI3).

EBI3 Binding (association) of p28 associated with epstein-barr virus

1) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.44 Pain Relevance 0.28

In addition to associating with p28 in IL-27, the EBi3 subunit can also couple with p35 to facilitate secretion of the latter [48].

EBi3 subunit Binding (associating) of p28

2) Confidence 0.04 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.74 Pain Relevance 0.28

The p28, protein was only found to be efficiently secreted when coupled with EBI3.

EBI3 Binding (coupled) of p28

3) Confidence 0.04 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

This test has worked.