INT23738

Context Info Confidence 0.26 First Reported 1986 Last Reported 2008 Negated 2 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 0.48 Pain Relevance 4.30

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency brain 2 dopaminergic neurons 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 26 100.00 cocaine 22 100.00 Opioid 4 100.00 mu opioid receptor 3 100.00 withdrawal 14 99.98 narcan 6 96.64 tolerance 6 95.96 midbrain 1 95.88 Enkephalin 6 94.64 Dynorphin 2 91.44

Disease Link Frequency Relevance Heat Stress 6 97.78 Drug Dependence 1 50.60 Recurrence 1 50.04 Ganglion Cysts 2 46.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect changes in the expression of delta- (DOR) kappa- (KOR) and mu- (MOR) opioid receptor mRNAs in rat cochleae at P0, P4, P8 and P16.

Regulation (changes) of Transcription (expression) of DOR associated with opioid receptor

1) Confidence 0.26 Published 2003 Journal Hear. Res. Section Abstract Doc Link 14553898 Disease Relevance 0 Pain Relevance 0.25

Thus, the result of this study did not suggest that alteration in transcription of gene-encoding delta-opioid receptor was responsible for the down-regulation of delta-opioid receptor associated with the development of tolerance to DADLE.

Regulation (alteration) of Transcription (transcription) of delta-opioid receptor associated with tolerance and opioid receptor

2) Confidence 0.24 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.65

Effect of chronic cocaine treatment on mu- and delta-opioid receptor mRNA levels in dopaminergically innervated brain regions.

Regulation (Effect) of Transcription (levels) of delta-opioid receptor in brain associated with opioid receptor and cocaine

3) Confidence 0.15 Published 1996 Journal J. Neurochem. Section Title Doc Link 8592112 Disease Relevance 0 Pain Relevance 0.80

While treatment with DAMGO (1 microM) or co-treatment with agmatine (1-100 nM) for 12 h failed to affect the mRNA level of micro opioid receptor.

Neg (failed) Regulation (affect) of Transcription (level) of micro opioid receptor associated with opioid receptor

4) Confidence 0.08 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18845140 Disease Relevance 0 Pain Relevance 0.50

Neither chronic cocaine nor its acute withdrawal altered amygdalar mu opioid receptor mRNA levels.

Neg (nor) Regulation (altered) of Transcription (levels) of opioid receptor associated with mu opioid receptor, withdrawal and cocaine

5) Confidence 0.06 Published 2005 Journal Neuroscience Section Abstract Doc Link 16039786 Disease Relevance 0.22 Pain Relevance 1.48

Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

Regulation (regulation) of Transcription (transcription) of opioid peptide in dopaminergic neurons associated with stress and opioid

6) Confidence 0.00 Published 1986 Journal Brain Res. Section Abstract Doc Link 2428438 Disease Relevance 0.25 Pain Relevance 0.61

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