INT237390

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.39
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Casz1) intracellular (Casz1) DNA binding (Casz1)
biological_process (Casz1) cytoplasm (Casz1)
Anatomy Link Frequency
cardiomyocytes 1
Heart 1
Casz1 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 27 100.00 Very High Very High Very High
Nicotine 6 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
ischemia 69 97.98 Very High Very High Very High
Migraine 45 62.00 Quite High
headache 64 58.80 Quite High
Pain 6 12.60 Low Low
adenocard 6 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 13 99.58 Very High Very High Very High
Reperfusion Injury 9 98.36 Very High Very High Very High
Cv Unclassified Under Development 69 97.98 Very High Very High Very High
Contracture 27 97.44 Very High Very High Very High
Injury 12 91.36 High High
Myocardial Infarction 33 73.28 Quite High
Migraine Disorders 48 62.00 Quite High
Headache 55 58.80 Quite High
Mental Disorders 4 17.00 Low Low
Pain 6 12.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, CST was found to be protective in a model of isolated cardiomyocytes exposed to simulated ischemia, increasing cell viability rate of about 65%.
Localization (found) of CST in cardiomyocytes associated with ischemia
1) Confidence 0.55 Published 2010 Journal Cell Mol Neurobiol Section Body Doc Link PMC3008938 Disease Relevance 0.42 Pain Relevance 0.14
Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart

The Chromogranin A (CgA)-derived anti-hypertensive peptide catestatin (CST) antagonizes catecholamine secretion, and is a negative myocardial inotrope acting via a nitric oxide-dependent mechanism.

Localization (secretion) of CST in Heart associated with reperfusion injury, catecholamine, ischemia and hypertension
2) Confidence 0.51 Published 2010 Journal Cell Mol Neurobiol Section Title Doc Link PMC3008938 Disease Relevance 0.72 Pain Relevance 0.22
CST (hCgA352–372; bCgA344–364), proteolytically processed from CgA, is the most potent endogenous antagonist of nicotinic-cholinergic receptor that inhibits nicotine-evoked catecholamine secretion in an autocrine/paracrine fashion (Mahata et al. 1997; 2010).
Localization (secretion) of CST associated with catecholamine, nicotine and antagonist
3) Confidence 0.48 Published 2010 Journal Cell Mol Neurobiol Section Body Doc Link PMC3008938 Disease Relevance 0.13 Pain Relevance 0.18
Videotapes of the first, third, fifth, and seventh treatment sessions are used to provide feedback to the therapist to ensure standardization of the CST and LSSM treatment protocols as well as to identify any differences in therapist-subject behavioral interactions between the CST and LSSM treatments and thus control for interactional bias.
Localization (standardization) of CST
4) Confidence 0.40 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2442042 Disease Relevance 0.12 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox