INT237409

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.31
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb4) mitochondrion (Erbb4) plasma membrane (Erbb4)
nucleus (Erbb4) kinase activity (Erbb4) cytoplasm (Erbb4)
Anatomy Link Frequency
Notch 2
Erbb4 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 117 99.04 Very High Very High Very High
monoamine 13 93.48 High High
Central nervous system 7 60.08 Quite High
antagonist 5 55.04 Quite High
cOX1 1 49.12 Quite Low
Inflammatory response 30 47.92 Quite Low
nMDA receptor 4 36.76 Quite Low
agonist 6 24.48 Low Low
Inflammation 132 21.68 Low Low
interneuron 2 14.28 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 163 97.92 Very High Very High Very High
Congenital Anomalies 10 92.60 High High
Disease 216 82.80 Quite High
Neurodegenerative Disease 12 77.00 Quite High
Nervous System Malformation 2 60.56 Quite High
Frontotemporal Dementia 16 59.44 Quite High
INFLAMMATION 175 50.00 Quite Low
Cognitive Disorder 50 44.96 Quite Low
Amyloid Plaque 33 40.88 Quite Low
Schizophrenia 15 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant differences in the expression of total EGF receptor or ErbB4 proteins were observed between controls and HB-EGF KO mice (P>0.05 vs. control mice) (Fig. 6a and b).
Localization (receptor) of ErbB4 associated with targeted disruption
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.70 Pain Relevance 0.05
-cleavage of APP, Notch and ErbB4.
Localization (cleavage) of ErbB4 in Notch
2) Confidence 0.55 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.14 Pain Relevance 0.70
-secretase releases the intracellular domain of ErbB4 (Ni et al., 2001), which then binds to TAB2 and the corepressor N-CoR (Sardi et al., 2006).
Localization (releases) of ErbB4
3) Confidence 0.55 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.39 Pain Relevance 0.03
Nonetheless, since NSAIDs, even at higher concentrations did not inhibit cleavage of Notch and ErbB4 or alter AICD formation, this class of inhibitors might be valuable compounds to selectively decrease A?
Localization (cleavage) of ErbB4 in Notch associated with cinod
4) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.08 Pain Relevance 0.64

General Comments

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