INT237410

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 57 99.24 Very High Very High Very High
cINOD 48 93.12 High High
cytokine 14 92.84 High High
Hippocampus 35 82.80 Quite High
agonist 4 73.12 Quite High
cerebral cortex 9 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 99.44 Very High Very High Very High
INFLAMMATION 68 99.24 Very High Very High Very High
Stress 94 93.68 High High
Targeted Disruption 61 90.32 High High
Disease 261 88.88 High High
Obesity 1 87.92 High High
Urological Neuroanatomy 2 66.84 Quite High
Disease Progression 6 63.12 Quite High
Gliosis 1 48.80 Quite Low
Death 10 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production possibly via increases in transcription of the BACE1 gene through this binding site [50].
Positive_regulation (increases) of Transcription (transcription) of BACE1 gene
1) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.51 Pain Relevance 0.04
However, during aging, wild-type mice undergo an increase in the relative abundance of the BACE1-I-501 variant.
Positive_regulation (increase) of Transcription (abundance) of BACE1-I-501 associated with aging
2) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.35 Pain Relevance 0
under inflammatory conditions, which would result in an increase in BACE1 transcription and A?
Positive_regulation (increase) of Transcription (transcription) of BACE1 associated with inflammation
3) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.67 Pain Relevance 0.45

General Comments

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