INT237414

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) cell differentiation (Jak2) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) histone binding (Jak2) enzyme binding (Bace1)
Anatomy Link Frequency
astrocytes 1
Jak2 (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 45 88.96 High High
Inflammation 46 82.52 Quite High
cytokine 11 76.88 Quite High
Hippocampus 4 67.92 Quite High
agonist 2 57.16 Quite High
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1 91.72 High High
Targeted Disruption 17 88.48 High High
INFLAMMATION 55 82.52 Quite High
Gliosis 1 81.20 Quite High
Amyloid Plaque 11 80.24 Quite High
Stress 3 77.72 Quite High
Disease 52 70.88 Quite High
Repression 2 35.84 Quite Low
Death 2 32.04 Quite Low
Alzheimer's Dementia 7 27.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated activation of JAK2 and ERK1/2, STAT1 binds to BACE1 promoter region to increase BACE1 protein expression in astrocytes [91].
JAK2 Binding (binds) of BACE1 in astrocytes
1) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.77 Pain Relevance 0.39

General Comments

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