INT237418

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) cell differentiation (Hif1a) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) protein binding transcription factor activity (Hif1a) enzyme binding (Bace1)
Hif1a (Mus musculus)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 83.72 Quite High
Inflammatory response 2 76.44 Quite High
Inflammation 46 75.12 Quite High
Eae 1 44.84 Quite Low
cytokine 11 41.08 Quite Low
antagonist 3 29.52 Quite Low
glial activation 2 17.96 Low Low
cINOD 45 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 1 95.36 Very High Very High Very High
Brain Injury 6 91.20 High High
Disease 52 78.76 Quite High
Injury 5 77.88 Quite High
INFLAMMATION 55 76.08 Quite High
Disease Progression 1 71.52 Quite High
Dementia 3 54.88 Quite High
Targeted Disruption 17 20.92 Low Low
Amyloid Plaque 11 20.00 Low Low
Cognitive Disorder 12 9.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This action is thought to be mediated by the binding of HIF-1 to the promoter region of BACE1 mRNA resulting in increased levels of BACE1 protein in the tissue [41].
HIF-1 Binding (binding) of BACE1
1) Confidence 0.06 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 1.18 Pain Relevance 0.15

General Comments

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