INT23744

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.93
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctrc)
Anatomy Link Frequency
pancreas 1
brain 1
cleavage 1
gland 1
Ctrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 6 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
substance P 20 99.84 Very High Very High Very High
fibrosis 1 96.64 Very High Very High Very High
tetrodotoxin 1 93.28 High High
Chronic pancreatitis 10 92.60 High High
agonist 1 86.32 High High
Inflammation 1 84.00 Quite High
Potency 2 83.44 Quite High
Enkephalin 2 76.96 Quite High
Disease Link Frequency Relevance Heat
Disease Susceptibility 1 97.52 Very High Very High Very High
Cystic Fibrosis 1 97.20 Very High Very High Very High
Disease 3 95.56 Very High Very High Very High
Pancreatitis 20 92.60 High High
INFLAMMATION 2 84.00 Quite High
Nutritional Deficiencies 2 77.72 Quite High
Calcification 2 75.00 Quite High
Diabetes Mellitus 5 72.76 Quite High
Abdominal Pain 1 70.44 Quite High
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When enzymatic digestion of PHEA hydrogel was evaluated using various concentrations of pepsin and alpha-chymotrypsin no degradation occurred within 24 h.
Protein_catabolism (degradation) of alpha-chymotrypsin
1) Confidence 0.62 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9401936 Disease Relevance 0.08 Pain Relevance 0.11
The recent identification of chymotrypsin C (CTRC) as enzyme Y, which was proposed to protect the pancreas by degrading prematurely activated trypsinogen within the pancreas 20 years ago, made CTRC an excellent candidate gene for disease-association studies.
Protein_catabolism (degrading) of CTRC in pancreas associated with disease
2) Confidence 0.62 Published 2008 Journal Hum. Genet. Section Abstract Doc Link 18172691 Disease Relevance 0.36 Pain Relevance 0.17
Metabolic stability of the analogues was measured by their ability to produce persistent K+ release from parotid slices, their half life time (t1/2) in the rat parotid and hypothalamic slice systems and their resistance to proteolytic cleavage by chymotrypsin, pepsin, papain and pronase.
Protein_catabolism (cleavage) of chymotrypsin in cleavage
3) Confidence 0.19 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2428641 Disease Relevance 0 Pain Relevance 0.52
These include alterations in genes coding for trypsinogens, the most abundant digestive enzymes (PRSS1 and PRSS2), the trypsin inhibitor (SPINK1) and the trypsin-degrading enzyme, chymotrypsinogen C (CTRC).
Protein_catabolism (degrading) of CTRC
4) Confidence 0.12 Published 2008 Journal Rev Endocr Metab Disord Section Abstract Doc Link 18604651 Disease Relevance 1.49 Pain Relevance 0.45
-chymotrypsin and thiol metalloproteinase insulin degrading enzymes.
Protein_catabolism (degrading) of chymotrypsin associated with metalloproteinase
5) Confidence 0.04 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.05
The addition of exogenous peptidases such as pronase, chymotrypsin and an extract of black widow spider venom gland dramatically increased the rate of degradation of SP, shortened the fading response and blocked the development of tachyphylaxis.
Protein_catabolism (degradation) of chymotrypsin in gland associated with substance p
6) Confidence 0.04 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6180910 Disease Relevance 0 Pain Relevance 0.52
With 3 proteases of different substrate specificities (trypsin, chymotrypsin and S. griseus protease) smooth microsomal opiate receptors from rat brain were consistently less sensitive to limited proteolysis than were synaptic membrane receptors.
Protein_catabolism (proteolysis) of chymotrypsin in brain associated with opiate
7) Confidence 0.02 Published 1982 Journal Brain Res. Section Abstract Doc Link 6291719 Disease Relevance 0 Pain Relevance 0.34
The puromycin-sensitive aminopeptidase was found to be resistant to proteolysis by trypsin, chymotrypsin, and protease V8 but was cleaved into an N-terminal 60-kDa fragment and a C-terminal 33-kDa fragment by proteinase K.
Protein_catabolism (proteolysis) of chymotrypsin
8) Confidence 0.01 Published 2003 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 12801515 Disease Relevance 0 Pain Relevance 0.03

General Comments

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