INT237464

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 96.12 Very High Very High Very High
Glutamate 2 88.84 High High
peripheral neuropathy 2 63.36 Quite High
cINOD 1 62.08 Quite High
palliative 4 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 98.24 Very High Very High Very High
Colon Cancer 3 90.00 High High
Leukemia 1 75.52 Quite High
Disorders Of Creatine Metabolism 1 73.76 Quite High
Stomach Cancer 24 64.88 Quite High
Peripheral Neuropathy 2 63.36 Quite High
Malignant Neoplastic Disease 5 50.00 Quite Low
Neuropathic Pain 3 40.88 Quite Low
Lung Cancer 47 38.64 Quite Low
Neutropenia 8 36.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduced level of TS mRNA might also lead to a lower TS protein expression, and make tumors more sensitive to 5-FU based chemotherapy [13,36,37].
Positive_regulation (lead) of Negative_regulation (reduced) of TS mRNA associated with cancer
1) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2442115 Disease Relevance 0.38 Pain Relevance 0.03
For example, the pentaglutamatation of pemetrexed increases its ability to inhibit thymidylate synthase 84-fold (Curtin and Hughes 2001).


Positive_regulation (increases) of Negative_regulation (inhibit) of thymidylate synthase
2) Confidence 0.14 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503655 Disease Relevance 0.15 Pain Relevance 0.20

General Comments

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