INT23763

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.22
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
plasma 2
cerebrospinal fluid 2
pituitary 2
corticotrophs 2
gut 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 9 100.00 Very High Very High Very High
narcan 9 100.00 Very High Very High Very High
Neurotransmitter 6 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
GABAergic 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Problems 2 83.92 Quite High
Body Weight 1 78.76 Quite High
Growth Hormone Deficiency 1 60.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc).
Regulation (control) of Localization (secretion) of CRH in gut associated with neurotransmitter, gabaergic, neuropeptide, somatostatin and opioid
1) Confidence 0.48 Published 1986 Journal Clin Endocrinol Metab Section Abstract Doc Link 2429794 Disease Relevance 0.08 Pain Relevance 0.34
These results show that modulation of peripheral plasma catecholamine levels within physiological limits does not affect CRF-stimulated release of ACTH or the adrenal response in normal man.
Neg (not) Regulation (affect) of Localization (release) of CRF in plasma associated with catecholamine
2) Confidence 0.45 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3024878 Disease Relevance 0 Pain Relevance 0.62
There were no significant changes compared to baseline in the cerebrospinal fluid concentrations of enkephalins, dynorphin A, the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl-ethyleneglycol, the serotonin metabolite 5-hydroxyindoleacetic acid, gamma-aminobutyric acid, somatostatin or corticotropin-releasing factor.
Regulation (concentrations) of Localization (releasing) of corticotropin-releasing factor in cerebrospinal fluid associated with dynorphin, somatostatin, enkephalin and serotonin
3) Confidence 0.23 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7537355 Disease Relevance 0.06 Pain Relevance 0.44
These effects appear to be mediated by changes in the secretion of the corticotropin-releasing hormone (CRH) and vasopressin into the hypophyseal portal circulation.
Regulation (changes) of Localization (secretion) of corticotropin-releasing hormone
4) Confidence 0.22 Published 1989 Journal Toxicol Pathol Section Abstract Doc Link 2571183 Disease Relevance 0 Pain Relevance 0.70
To further investigate the role of opioids in the regulation of the pituitary-adrenal axis we studied the effect of morphine and naloxone on human corticotropin-releasing hormone (hCRH)-induced ACTH, immunoreactive (ir) beta-endorphin, and cortisol release in normal subjects.
Regulation (effect) of Localization (release) of hCRH in pituitary associated with narcan, opioid and morphine
5) Confidence 0.21 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3033966 Disease Relevance 0 Pain Relevance 0.60
It is suggested that naloxone acts by antagonizing an inhibitory ultra-short-loop feedback effect of coreleased beta-endorphin on pituitary corticotrophs, thereby amplifying the net effect of hCRF, i.e., the release of ACTH.
Regulation (effect) of Localization (release) of hCRF in corticotrophs associated with narcan
6) Confidence 0.00 Published 1987 Journal Klin. Wochenschr. Section Abstract Doc Link 3037181 Disease Relevance 0.08 Pain Relevance 0.33

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