INT23764

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.75
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
gut 2
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
qutenza 5 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
GABAergic 1 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
dexamethasone 1 99.80 Very High Very High Very High
Bioavailability 1 93.16 High High
antagonist 1 86.52 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 99.32 Very High Very High Very High
Respiratory Distress 3 87.48 High High
Growth Problems 2 84.32 Quite High
Barotrauma 1 73.52 Quite High
Ocular Toxicity (including Many Sub-types) 1 73.04 Quite High
Bronchopulmonary Dysplasia 1 71.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effect of combined administration of TRH and dexamethasone in pregnant women and the course of their pregnancy].
Regulation ([Effect) of Localization (administration) of TRH associated with dexamethasone
1) Confidence 0.45 Published 1998 Journal Ceska Gynekol Section Title Doc Link 10535166 Disease Relevance 0.47 Pain Relevance 0.11
Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.
Regulation (Role) of Localization (releasing) of thyrotropin-releasing hormone associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
2) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10513557 Disease Relevance 0.19 Pain Relevance 0.77
The developed formulation provided more prolonged and controlled TRH release compared to the marketed formulation.
Regulation (controlled) of Localization (release) of TRH
3) Confidence 0.42 Published 2009 Journal Acta Pharm Section Abstract Doc Link 19304555 Disease Relevance 0 Pain Relevance 0.18
Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc).
Regulation (control) of Localization (secretion) of TRH in gut associated with neurotransmitter, gabaergic, neuropeptide, somatostatin and opioid
4) Confidence 0.32 Published 1986 Journal Clin Endocrinol Metab Section Abstract Doc Link 2429794 Disease Relevance 0.08 Pain Relevance 0.34

General Comments

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