INT237641

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cntnap1, Nfasc) signal transduction (Cntnap1) plasma membrane (Nfasc)
cytoskeleton organization (Cntnap1)
Anatomy Link Frequency
node 1
bands 1
Cntnap1 (Mus musculus)
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 75 84.36 Quite High
Nav1.6 7 79.12 Quite High
sodium channel 43 71.36 Quite High
potassium channel 18 5.00 Very Low Very Low Very Low
Spinal cord 16 5.00 Very Low Very Low Very Low
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Nav1.2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 17 100.00 Very High Very High Very High
Demyelinating Disease 11 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Adrenoleukodystrophy 1 5.00 Very Low Very Low Very Low
Lipidosis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in the case of the ceramide galactosyltransferase mutant mice, Nfasc186 delivered to the axolemma, possibly guided by local concentrations of Caspr and Contactin, might drive the assembly of the node in the absence of the paranodal junction.
Caspr Binding (concentrations) of Nfasc186 in node
1) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.21
For example, the assembly of paranodal axoglial junctions (appearing as transverse bands in freeze-fracture replicas) requires association of the adhesion protein neurofascin-155 expressed by oligodendrocytes with the axonal caspr-contactin heteromer (Charles et al., 2002).
caspr-contactin heteromer Binding (association) of neurofascin-155 in bands associated with adhesions
2) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0.10 Pain Relevance 0.08

General Comments

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