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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sfn) nucleus (Sfn) cytoplasm (Sfn)
Anatomy Link Frequency
Skin 1
leg 1
Sfn (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 2 97.40 Very High Very High Very High
qutenza 2 95.52 Very High Very High Very High
c fibre 16 94.48 High High
unmyelinated 4 94.12 High High
peripheral neuropathy 6 62.44 Quite High
Neuropathic pain 36 52.80 Quite High
Pain 114 42.32 Quite Low
spinal stenosis 2 32.24 Quite Low
Hypoesthesia 8 27.64 Quite Low
tolerance 12 21.68 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 356 100.00 Very High Very High Very High
Diabetes Mellitus 22 78.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 77.12 Quite High
Infection 4 76.80 Quite High
Syndrome 14 72.68 Quite High
Increased Venous Pressure Under Development 20 62.72 Quite High
Non-diabetic Peripheral Neuropathy 16 62.44 Quite High
Pain 128 42.32 Quite Low
Spinal Cord Diseases 4 32.72 Quite Low
Spinal Stenosis 2 32.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skin biopsy can reliably demonstrate the loss of IENF in SFN, thus confirming the diagnosis when clinical and neurophysiologic examinations are not informative (Lauria et al., 2005; Gibbons et al., 2006).
Negative_regulation (loss) of SFN in Skin associated with neuropathic pain
1) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 0.93 Pain Relevance 0.42
LEPs were recorded in all healthy subjects and in most SFN patients after stimulation of hand, foot and distal leg.
Negative_regulation (recorded) of SFN in leg associated with neuropathic pain
2) Confidence 0.32 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 0.77 Pain Relevance 0.07
Because our study showed that knockdown of endogenous CRIF1 enhanced SFN-induced NRF2 total and nuclear expression (Fig. 3, C and D), we determined whether the induced nuclear NRF2 binds to an ARE-containing DNA sequence.
Negative_regulation (knockdown) of SFN-induced
3) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0

General Comments

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