INT237653

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.54
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sfn) nucleus (Sfn) cytoplasm (Sfn)
Anatomy Link Frequency
pupils 1
Sfn (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 40 92.96 High High
Spontaneous pain 45 92.32 High High
allodynia 90 90.88 High High
Quantitative sensory testing 180 87.12 High High
Hyperalgesia 40 83.92 Quite High
visual analogue scale 25 79.84 Quite High
peripheral neuropathy 15 79.60 Quite High
Pain 285 76.20 Quite High
hypoalgesia 5 71.48 Quite High
Pain threshold 5 67.52 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 890 100.00 Very High Very High Very High
Neuropathy 10 99.90 Very High Very High Very High
Increased Venous Pressure Under Development 50 98.00 Very High Very High Very High
Diabetic Nephropathy 25 97.52 Very High Very High Very High
Congenital Anomalies 15 94.12 High High
Pain 320 91.36 High High
Hyperalgesia 40 83.92 Quite High
Non-diabetic Peripheral Neuropathy 40 79.60 Quite High
Hypoalagesia 5 71.48 Quite High
Hypesthesia 20 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced epidermal innervation density has been used as mandatory criteria for diagnosing SFN (Holland et al., 1998).
Gene_expression (diagnosing) of SFN associated with neuropathic pain
1) Confidence 0.59 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 1.02 Pain Relevance 0.44
Polyneuropathy was distinguished in SFN, large fibre neuropathy (LFN) and mixed (large and small) fibre neuropathy (MFN).
Gene_expression (distinguished) of SFN associated with neuropathy and neuropathic pain
2) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 2.01 Pain Relevance 0.89
Criteria to diagnose SFN
Gene_expression (diagnose) of SFN associated with neuropathic pain
3) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 0.79 Pain Relevance 0.54
Clinical signs of autonomic dysfunction were present in 32 patients (47.8%) with SFN: 18 patients had hypo-anidrosis, 12 patients had flushing or other vasomotor dysfunctions and two patients had Adie's pupils with post-ganglionic hypersensibility to 0.1% pilocarpine test.
Gene_expression (present) of SFN in pupils associated with neuropathic pain and increased venous pressure under development
4) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 0.90 Pain Relevance 0.29
LEPs in SFN
Gene_expression (LEPs) of SFN associated with neuropathic pain
5) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2442424 Disease Relevance 0.83 Pain Relevance 0.09
Because our study showed that knockdown of endogenous CRIF1 enhanced SFN-induced NRF2 total and nuclear expression (Fig. 3, C and D), we determined whether the induced nuclear NRF2 binds to an ARE-containing DNA sequence.
Gene_expression (expression) of SFN-induced
6) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0

General Comments

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