INT237669

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1)
nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)
PDB1 (Homo sapiens)
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 40.96 Quite Low
Osteoarthritis 4 35.84 Quite Low
Arthritis 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 54 100.00 Very High Very High Very High
Infection 2 99.86 Very High Very High Very High
Measles 2 99.54 Very High Very High Very High
Viral Infection 2 97.84 Very High Very High Very High
Disease 204 87.24 High High
Pain 6 40.96 Quite Low
Osteoarthritis 4 35.84 Quite Low
Deafness 6 34.68 Quite Low
Spontaneous Fractures 2 34.28 Quite Low
Hypercalcemia 4 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This has led to the suggestion that environmental factors such as measles virus infection might interact with SQSTM1 mutations to cause PDB [11].
PDB Spec (might) Binding (interact) of SQSTM1 associated with measles, bone disease and infection
1) Confidence 0.27 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2442429 Disease Relevance 1.34 Pain Relevance 0
Importantly, mutations of SQSTM1 are highly specific for PDB and have not been found in unaffected age matched controls derived from the general population in any of the studies that have been performed so far [9,14-17].
PDB Binding (specific) of SQSTM1 associated with bone disease
2) Confidence 0.27 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2442429 Disease Relevance 1.21 Pain Relevance 0

General Comments

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