INT23770

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Context Info
Confidence 0.19
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) extracellular region (Tpsab1)
Anatomy Link Frequency
mast cell 1
Tpsab1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 14 99.96 Very High Very High Very High
tetrodotoxin 2 97.92 Very High Very High Very High
Opioid 3 75.00 Quite High
cytokine 3 56.28 Quite High
ischemia 47 50.00 Quite Low
anesthesia 2 50.00 Quite Low
antagonist 2 38.80 Quite Low
MU agonist 1 29.52 Quite Low
Enkephalin 1 27.28 Quite Low
agonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 29 50.00 Quite Low
Mastocytosis 5 50.00 Quite Low
Cv Unclassified Under Development 29 49.60 Quite Low
Cv General 4 Under Development 17 5.00 Very Low Very Low Very Low
Injury 13 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Hemorrhage 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Wound Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SM in children is extremely rare and is associated with elevated baseline serum tryptase.
tryptase Binding (associated) of
1) Confidence 0.19 Published 2009 Journal Paediatr Anaesth Section Body Doc Link 19207896 Disease Relevance 0 Pain Relevance 0
Brownish granules in the cytoplasm were recognized as positive staining for tryptase.
tryptase Binding (recognized) of
2) Confidence 0.16 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0 Pain Relevance 0.03
Alpha beta 1 bound [3H]saxitoxin with a KD of 4.1 nM at 36 degrees C.
Alpha beta 1 Binding (bound) of
3) Confidence 0.11 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2429961 Disease Relevance 0 Pain Relevance 0.32
Like intact sodium channels, alpha beta 1 bound 125I-LqTx in a voltage-dependent manner with a KD of approximately 6 nM at a membrane potential of -60 mV and was specifically covalently labeled by azidonitrobenzoyl 125I-LqTx.
alpha beta 1 Binding (bound) of associated with sodium channel
4) Confidence 0.08 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2429961 Disease Relevance 0 Pain Relevance 0.37
Trypsin and mast cell tryptase cleave within the extracellular N terminus of proteinase-activated receptor-2 (PAR-2), exposing a tethered ligand (SLIGRL) that binds and activates the cleaved receptor.
tryptase Binding (binds) of in mast cell
5) Confidence 0.01 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10992008 Disease Relevance 0 Pain Relevance 0.07

General Comments

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