INT237741

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.56
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) aging (Serpinf1) extracellular region (Serpinf1)
cellular_component (Serpinf1)
Serpinf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 112 98.52 Very High Very High Very High
Inflammatory response 28 70.04 Quite High
ischemia 4 46.96 Quite Low
Inflammatory marker 4 26.60 Quite Low
cytokine 16 9.28 Low Low
GABA receptor 4 7.04 Low Low
chemokine 12 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
gABA 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 128 98.80 Very High Very High Very High
INFLAMMATION 144 98.52 Very High Very High Very High
Stress 8 88.08 High High
Diabetes Mellitus 232 86.32 High High
Apoptosis 56 86.16 High High
Shock 4 81.84 Quite High
Adhesions 20 62.52 Quite High
Retina Disease 4 46.96 Quite Low
Insulin Resistance 4 33.72 Quite Low
Epiretinal Membrane 4 22.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of PEDF associated with inflammation
1) Confidence 0.25 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
In fact, increased vitreal levels of PEDF have been described in other DR clinical reports [13].
Positive_regulation (increased) of PEDF associated with diabetic retinopathy
2) Confidence 0.22 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.14 Pain Relevance 0.15
We also observe an induction of PEDF and more studies will be needed to determine if PEDF induction is a compensatory response to other inflammatory and angiogenic changes or if it has a different purpose.
Positive_regulation (induction) of PEDF associated with inflammation
3) Confidence 0.22 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.02 Pain Relevance 0.15
We also observe an induction of PEDF and more studies will be needed to determine if PEDF induction is a compensatory response to other inflammatory and angiogenic changes or if it has a different purpose.
Positive_regulation (induction) of PEDF associated with inflammation
4) Confidence 0.22 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.08 Pain Relevance 0.15

General Comments

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