INT237744

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Chi3l1) extracellular region (Chi3l1) endoplasmic reticulum (Chi3l1)
carbohydrate metabolic process (Chi3l1) molecular_function (Chi3l1) cytoplasm (Chi3l1)
Chi3l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 12 100.00 Very High Very High Very High
Inflammation 28 99.10 Very High Very High Very High
GABAergic 17 98.04 Very High Very High Very High
gABA 6 85.60 High High
Rostral ventrolateral medulla 1 79.24 Quite High
Spinal cord 16 73.24 Quite High
potassium channel 3 23.84 Low Low
agonist 11 15.36 Low Low
Neurotransmitter 1 11.04 Low Low
GABA receptor 1 8.88 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.10 Very High Very High Very High
Urological Neuroanatomy 15 92.72 High High
Diabetic Retinopathy 32 82.96 Quite High
Hypotension 1 66.76 Quite High
Diabetes Mellitus 58 50.00 Quite Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Edema 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of CHI3L1 associated with inflammation
1) Confidence 0.40 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
Preincubation of GABAB receptor antagonist CGP55845 had no significant effect on evoked IPSPs from both pathways.
Positive_regulation (Preincubation) of CGP55845 associated with antagonist
2) Confidence 0.06 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.25 Pain Relevance 0.40

General Comments

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