INT237748

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Jak3, Stat3) transcription factor binding (Jak3, Stat3) DNA binding (Stat3)
signal transducer activity (Stat3) cell proliferation (Stat3) nucleolus (Stat3)
Jak3 (Rattus norvegicus)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 99.70 Very High Very High Very High
chemokine 3 75.56 Quite High
Inflammatory response 7 72.24 Quite High
Inflammatory marker 1 71.60 Quite High
Inflammation 28 67.28 Quite High
ischemia 1 30.00 Quite Low
ketamine 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
GABA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 58 91.32 High High
Ganglion Cysts 3 90.80 High High
Epiretinal Membrane 1 79.60 Quite High
INFLAMMATION 36 71.88 Quite High
Diabetic Retinopathy 32 59.52 Quite High
Insulin Resistance 1 57.28 Quite High
Retina Disease 1 30.64 Quite Low
Adhesions 5 16.48 Low Low
Neurodegenerative Disease 2 10.48 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JAK3 (janus kinase 3) expression requires cytokine signaling and inhibition of JAK3 prevents STAT3 activation [36].
Negative_regulation (inhibition) of JAK3 Negative_regulation (prevents) of Positive_regulation (activation) of STAT3 associated with cytokine
1) Confidence 0.25 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.01 Pain Relevance 0.22

General Comments

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