INT237794

Context Info Confidence 0.70 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.27 Pain Relevance 0.16

transport (Stim1) endoplasmic reticulum (Stim1) plasma membrane (Stim1) cytoskeleton (Stim1) cytoplasm (Stim1)

Anatomy Link Frequency reticulum 1 Stim1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 4 86.48 agonist 42 76.92 cva 12 41.52 imagery 14 40.40 ischemia 12 36.24 Potency 4 5.00 TRP channel 2 5.00 Versed 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Thrombosis 56 92.84 Brain Hemorrhage 32 90.96 Cv General 4 Under Development 12 76.12 Adhesions 8 75.92 Vasculitis 2 73.00 Pressure Volume 2 Under Development 4 71.88 Injury 12 71.80 Pressure And Volume Under Development 2 58.56 Hemorrhage 30 55.28 Infarction 8 42.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Platelets express high levels of STIM1, but its exact function has been elusive, because these cells lack a normal ER and Ca2+ is stored in a tubular system referred to as the sarcoplasmatic reticulum.

Positive_regulation (levels) of STIM1 in reticulum

1) Confidence 0.70 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442636 Disease Relevance 0.76 Pain Relevance 0.08

Experiments were conducted on 10–12-wk-old Stim1?

Positive_regulation (conducted) of Stim1

2) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.51 Pain Relevance 0.09

General Comments

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