INT237801

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.94
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Stim1) endoplasmic reticulum (Stim1) plasma membrane (Stim1)
cytoskeleton (Stim1) cytoplasm (Stim1)
Anatomy Link Frequency
platelets 3
reticulum 1
Stim1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 6 98.36 Very High Very High Very High
agonist 126 77.44 Quite High
cva 36 34.72 Quite Low
Potency 12 30.72 Quite Low
ischemia 36 26.36 Quite Low
imagery 42 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 6 97.08 Very High Very High Very High
Brain Hemorrhage 96 89.04 High High
Thrombosis 168 87.84 High High
Cv General 4 Under Development 36 76.64 Quite High
Vasculitis 6 73.52 Quite High
Pressure Volume 2 Under Development 12 72.40 Quite High
Hemorrhage 90 70.96 Quite High
Cyanosis 6 48.64 Quite Low
Death 24 46.56 Quite Low
Disease 6 41.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In platelets, STIM1 is expressed at high levels (14) and may contribute to SOCE by interacting with TRPC1 (15).
Gene_expression (expressed) of STIM1 in platelets
1) Confidence 0.78 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.25 Pain Relevance 0.08
Platelets express high levels of STIM1, but its exact function has been elusive, because these cells lack a normal ER and Ca2+ is stored in a tubular system referred to as the sarcoplasmatic reticulum.
Gene_expression (express) of STIM1 in reticulum
2) Confidence 0.78 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442636 Disease Relevance 0.76 Pain Relevance 0.08
We recently reported that mice expressing an activating EF-hand mutant of STIM1 have elevated [Ca2+]i levels in platelets, macrothrombocytopenia, and a bleeding disorder, indicating a role for STIM1-dependent SOCE in platelet function (14).
Gene_expression (expressing) of STIM1 in platelets associated with coagulation disorder
3) Confidence 0.78 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.18 Pain Relevance 0.07
This could also explain why platelets expressing an activating EF-hand mutant of STIM1 that leads to elevated basal [Ca2+]i levels display a selective GPVI/PLC?
Gene_expression (expressing) of STIM1 in platelets
4) Confidence 0.60 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.05 Pain Relevance 0.06
The generation of Stim1?
Gene_expression (generation) of Stim1
5) Confidence 0.60 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.38 Pain Relevance 0
mice, which were intercrossed to produce Stim1?
Gene_expression (produce) of Stim1
6) Confidence 0.53 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.31 Pain Relevance 0

General Comments

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