INT237807

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.55
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Stim1) endoplasmic reticulum (Stim1) plasma membrane (Stim1)
cytoskeleton (Stim1) cytoplasm (Stim1)
Anatomy Link Frequency
platelet 1
Stim1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 105 91.28 High High
Versed 5 81.28 Quite High
antagonist 5 76.64 Quite High
TRP channel 5 75.60 Quite High
ischemia 30 52.96 Quite High
cva 30 11.96 Low Low
imagery 35 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 30 99.12 Very High Very High Very High
Cyanosis 5 96.08 Very High Very High Very High
Hemorrhage 75 95.84 Very High Very High Very High
Death 20 94.00 High High
Thrombosis 140 93.76 High High
Coagulation Disorder 5 87.92 High High
Brain Hemorrhage 80 74.08 Quite High
Cv General 4 Under Development 30 68.16 Quite High
Vasculitis 5 65.04 Quite High
Pressure Volume 2 Under Development 10 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address the function of STIM1 in vivo, the Stim1 gene was disrupted in mice by insertion of an intronic gene trap cassette.
Negative_regulation (disrupted) of Stim1
1) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.34 Pain Relevance 0.04
We report that mice lacking STIM1 display early postnatal lethality and growth retardation.
Negative_regulation (lacking) of STIM1
2) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442636 Disease Relevance 0.78 Pain Relevance 0.08
70%) of mice lacking STIM1 (Stim1?
Negative_regulation (lacking) of Stim1
3) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.36 Pain Relevance 0.03
mice were injected intravenously into the irradiated mice (4 × 106 cells per mouse). 4 wk after transplant, platelet counts were determined and STIM1 deficiency was confirmed by Western blotting.
Negative_regulation (deficiency) of STIM1 in platelet
4) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0 Pain Relevance 0.08
To test whether the defect in Stim1?
Spec (whether) Negative_regulation (defect) of Stim1
5) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 1.08 Pain Relevance 0.03

General Comments

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