INT237815

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.07

transport (Itpr3, Stim1) endoplasmic reticulum (Itpr3, Stim1) cytoplasm (Itpr3, Stim1) nucleoplasm (Itpr3) transmembrane transport (Itpr3) nucleolus (Itpr3)

Anatomy Link Frequency mast cells 1 Itpr3 (Mus musculus) Stim1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 21 81.72 imagery 7 9.32 ischemia 6 5.00 cva 6 5.00 anesthesia 2 5.00 Potency 2 5.00 TRP channel 1 5.00 Versed 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Thrombosis 28 50.00 Brain Hemorrhage 16 20.72 Infarction 4 15.32 Hemorrhage 15 6.64 Cv General 4 Under Development 6 5.00 Injury 6 5.00 Death 4 5.00 Adhesions 4 5.00 Transient Ischemic Attack 3 5.00 Pressure Volume 2 Under Development 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, mast cells lacking the major SOC channel Orai1 (22) show normal store content, suggesting a SOC channel–independent role of STIM1 in store refill, possibly through interaction with the IP3 receptors or SERCA pumps in the SR/ER.

IP3 Binding (interaction) of STIM1 in mast cells

1) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.