INT23784

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 2.89
Pain Relevance 17.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
saphenous veins 1
ileum 1
subthalamic nucleus 1
amygdala 1
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 45 100.00 Very High Very High Very High
Enkephalin 24 100.00 Very High Very High Very High
addiction 10 99.96 Very High Very High Very High
antinociception 3 99.84 Very High Very High Very High
qutenza 3 99.80 Very High Very High Very High
Morphine 41 99.76 Very High Very High Very High
amygdala 6 99.68 Very High Very High Very High
adenocard 16 99.60 Very High Very High Very High
opiate 21 99.56 Very High Very High Very High
Inflammation 1 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 100.00 Very High Very High Very High
INFLAMMATION 2 99.54 Very High Very High Very High
Bordatella Infection 4 99.48 Very High Very High Very High
Nociception 4 98.40 Very High Very High Very High
Contracture 4 97.56 Very High Very High Very High
Adhesions 6 93.72 High High
Pain 85 93.40 High High
Constipation 2 84.68 Quite High
Drug Dependence 4 77.48 Quite High
Neuroblastoma 2 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The labeling of the receptor by agonist was decreased by nonhydrolyzable GTP analogs and by pertussis toxin treatment of cells expressing the human mu receptor, consistent with the coupling of the receptor to guanine nucleotide binding proteins.
Gene_expression (expressing) of mu receptor associated with bordatella infection and agonist
1) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815359 Disease Relevance 0.16 Pain Relevance 0.62
We have also investigated the distribution of mRNAs encoding the mu receptor in human brain by Northern analysis, which demonstrates the existence of multiple transcripts of 13.5, 11, 4.3 and 2.8 kb, which were highly expressed in the hypothalamus, thalamus and subthalamic nucleus, more moderately expressed in the amygdala and caudate nucleus and which demonstrated lowest levels of expression in the hippocampus, substantia nigra and corpus callosum.
Gene_expression (expressed) of mu receptor in thalamus associated with substantia nigra, hippocampus, thalamus and amygdala
2) Confidence 0.55 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815359 Disease Relevance 0.14 Pain Relevance 0.61
We described previously the involvement of protein kinase C and G-protein-coupled receptor kinases (GRK) 2 and 3 in OFQ/N-induced mu receptor desensitization.
Gene_expression (desensitization) of mu receptor associated with kinase c
3) Confidence 0.52 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15890842 Disease Relevance 0.07 Pain Relevance 0.62
The importance of visual imagery and relational thinking manifests itself in a heuristic approach to the design and synthesis of potential morphinomimetics as agonists of the human mu receptor.
Gene_expression (synthesis) of mu receptor associated with agonist and imagery
4) Confidence 0.49 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12502358 Disease Relevance 0 Pain Relevance 0.33
To determine whether protein expressed from this cDNA exhibits the biochemical characteristics expected of the mu 3 receptor, the cDNA clone was expressed in a heterologous system.
Gene_expression (expected) of mu 3 receptor
5) Confidence 0.42 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12734358 Disease Relevance 0 Pain Relevance 1.03
CONCLUSIONS: The individual variations in mu receptor expression in these vascular tissues may explain the large variance in graft survival using saphenous veins for coronary artery bypass surgery.


Gene_expression (expression) of mu receptor in saphenous veins
6) Confidence 0.27 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15448587 Disease Relevance 0 Pain Relevance 0
At 2 and 6 hours, a rebound effect was observed as noted by an increase in mu receptor expression, and at 24 hours mu receptor expression returned to control levels in the SNAP-treated cells.
Gene_expression (expression) of mu receptor
7) Confidence 0.27 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11687719 Disease Relevance 0 Pain Relevance 0
In this report, we show by real-time RT-PCR that the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) initiates the down regulation of mu receptor gene expression in human mononuclear cells after 30 minutes.
Gene_expression (expression) of mu receptor gene in mononuclear cells
8) Confidence 0.27 Published 2001 Journal Med. Sci. Monit. Section Abstract Doc Link 11687719 Disease Relevance 0 Pain Relevance 0.25
At 2 and 6 hours, a rebound effect was observed as noted by an increase in mu receptor expression, and at 24 hours mu receptor expression returned to control levels in the SNAP-treated cells.
Gene_expression (expression) of mu receptor
9) Confidence 0.27 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11687719 Disease Relevance 0 Pain Relevance 0
BACKGROUND: In previous studies, we have attributed opiate alkaloid selectivity to a subtype of the neuronal mu receptor known as mu3, expressed on human blood cells.
Gene_expression (expressed) of mu receptor in blood cells associated with opiate
10) Confidence 0.23 Published 2001 Journal Med. Sci. Monit. Section Abstract Doc Link 11687719 Disease Relevance 0 Pain Relevance 0.27
It does not produce persistent binding of the mu receptor, which would prevent the action of other opioids in acute and chronic painful conditions (Walsh et al 1995); as a result other opioids can be used for breakthrough pain in the presence of buprenorphine (Budd and Collett 2003).


Neg (not) Gene_expression (produce) of mu receptor associated with pain, breakthrough pain, opioid and buprenorphine
11) Confidence 0.22 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.51 Pain Relevance 2.23
We have also investigated the distribution of mRNAs encoding the mu receptor in human brain by Northern analysis, which demonstrates the existence of multiple transcripts of 13.5, 11, 4.3 and 2.8 kb, which were highly expressed in the hypothalamus, thalamus and subthalamic nucleus, more moderately expressed in the amygdala and caudate nucleus and which demonstrated lowest levels of expression in the hippocampus, substantia nigra and corpus callosum.
Gene_expression (expressed) of mu receptor in subthalamic nucleus associated with substantia nigra, hippocampus, thalamus and amygdala
12) Confidence 0.19 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815359 Disease Relevance 0.14 Pain Relevance 0.61
We have also investigated the distribution of mRNAs encoding the mu receptor in human brain by Northern analysis, which demonstrates the existence of multiple transcripts of 13.5, 11, 4.3 and 2.8 kb, which were highly expressed in the hypothalamus, thalamus and subthalamic nucleus, more moderately expressed in the amygdala and caudate nucleus and which demonstrated lowest levels of expression in the hippocampus, substantia nigra and corpus callosum.
Gene_expression (expressed) of mu receptor in hypothalamus associated with substantia nigra, hippocampus, thalamus and amygdala
13) Confidence 0.19 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7815359 Disease Relevance 0.14 Pain Relevance 0.61
CHO cells expressing the cloned human mu-receptor were treated for 20 h with 10 microM DAMGO, HERK, morphine, or medium.
Gene_expression (expressing) of mu-receptor associated with morphine
14) Confidence 0.19 Published 2007 Journal Synapse Section Abstract Doc Link 17152090 Disease Relevance 0 Pain Relevance 0.57
Peripheral inflammation causes an increase in mu receptor levels on peripheral terminals of primary afferent neurons.
Gene_expression (levels) of mu receptor in afferent neurons associated with inflammation
15) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054115 Disease Relevance 0.10 Pain Relevance 0.33
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Gene_expression (expression) of mu receptor in amygdala associated with cannabis and amygdala
16) Confidence 0.08 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.83
Unexpectedly, no expression of the mu receptor was detected.
Gene_expression (expression) of mu receptor
17) Confidence 0.07 Published 1995 Journal FEBS Lett. Section Abstract Doc Link 7649271 Disease Relevance 0 Pain Relevance 0.22
For the experiments Chinese hamster ovary cells, stably expressing human mu-receptor, were used.
Gene_expression (expressing) of mu-receptor in ovary
18) Confidence 0.03 Published 2007 Journal Chemical biology & drug design Section Abstract Doc Link 17718719 Disease Relevance 0 Pain Relevance 0.62
This study has shown that mu receptor agonists produced dependence in the guinea-pig ileum revealed by a withdrawal contracture on addition of naloxone, whereas dependence on kappa receptor agonists could not be revealed with naloxone.
Gene_expression (produced) of mu receptor in ileum associated with addiction, narcan, agonist, contracture and withdrawal
19) Confidence 0.01 Published 1986 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2430191 Disease Relevance 0.30 Pain Relevance 2.42
We used CHO cells expressing the cloned human mu receptor, cloned human delta receptor, or cloned mouse delta/human mu ("dimer cell").
Gene_expression (expressing) of mu receptor
20) Confidence 0.01 Published 2008 Journal Peptides Section Abstract Doc Link 18472184 Disease Relevance 0 Pain Relevance 0.38

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