INT237858

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.93
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYD88) signal transduction (MYD88) plasma membrane (MYD88)
intracellular (MYD88) cytoplasm (MYD88)
Anatomy Link Frequency
macrophages 1
NK cells 1
MYD88 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 106 87.52 High High
Opioid 67 83.92 Quite High
cytokine 41 81.44 Quite High
Inflammatory response 9 80.52 Quite High
addiction 4 70.96 Quite High
analgesia 20 70.48 Quite High
agonist 22 63.20 Quite High
IPN 19 60.56 Quite High
Pain 28 55.28 Quite High
Endogenous opioid 2 44.32 Quite Low
Disease Link Frequency Relevance Heat
Sepsis 65 98.66 Very High Very High Very High
Obesity 20 95.56 Very High Very High Very High
Malaria 12 92.96 High High
INFLAMMATION 119 87.52 High High
Infection 55 84.76 Quite High
Cerebral Malaria 152 82.64 Quite High
Insulin Resistance 20 79.60 Quite High
Anaemia 20 62.56 Quite High
Inflammatory Pain 19 60.56 Quite High
Pain 29 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production, which depends on IL18R/MyD88 signaling on both macrophages and NK cells [35].
Positive_regulation (depends) of MyD88 in NK cells
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.81 Pain Relevance 0.06
While most TLRs signal through the Myd88 pathway (Myeloid differentiation factor-88), TLR 3 and 4 utilize the TRIF pathway (TIR domain-containing adapter protein that induces IFN-?)
Positive_regulation (pathway) of Myd88
2) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.16 Pain Relevance 0.03
Fig. 3 shows that sepsis induced TLR4 protein levels and activation, as demonstrated by an increase in TLR4/MyD88 interaction in the three tissues investigated, and atorvastatin reduced this early step of TLR4 activation and also TLR4 expression (Fig. 3A–C).
Positive_regulation (increase) of MyD88 associated with sepsis
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.92 Pain Relevance 0.20
production, which depends on IL18R/MyD88 signaling on both macrophages and NK cells [35].
Positive_regulation (depends) of MyD88 in macrophages
4) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.81 Pain Relevance 0.06
In contrast, TLR activation induces coupling to an adapter protein, MyD88, and stimulation of several intrinsic kinases including interleukin-1 receptor accessory protein kinase leading to NF-?
Positive_regulation (stimulation) of MyD88
5) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.23 Pain Relevance 0.54

General Comments

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