INT23786

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.21
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
neuronal 2
autonomic 2
parenchyma 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 20 100.00 Very High Very High Very High
agonist 6 99.98 Very High Very High Very High
Spinal cord 24 99.06 Very High Very High Very High
Pain 35 97.60 Very High Very High Very High
Neuronal excitability 1 96.24 Very High Very High Very High
Inflammation 28 94.28 High High
antagonist 50 93.76 High High
cytokine 16 90.00 High High
nMDA receptor 3 77.76 Quite High
Dorsal horn neuron 4 66.64 Quite High
Disease Link Frequency Relevance Heat
Injury 10 99.72 Very High Very High Very High
Nociception 7 99.08 Very High Very High Very High
Pain 49 97.60 Very High Very High Very High
INFLAMMATION 31 94.28 High High
Status Epilepticus 106 91.04 High High
Urological Neuroanatomy 19 78.56 Quite High
Suicidal Behaviour 1 75.76 Quite High
Ganglion Cysts 1 71.04 Quite High
Hyperalgesia 8 58.08 Quite High
Neuropathic Pain 81 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Receptor autoradiography showed the discrete localization of substance P binding sites in both sensory and motor regions of the spinal cord and functional studies suggested an important role for substance P receptor activation in autonomic outflow, nociception, respiration and somatic motor function.
Positive_regulation (role) of Positive_regulation (activation) of P receptor in autonomic associated with nociception, spinal cord and substance p
1) Confidence 0.44 Published 1986 Journal Neuroscience Section Abstract Doc Link 2430231 Disease Relevance 0.36 Pain Relevance 0.51
Further electrophysiological studies showed that prolonged agonist activation of P2X7 receptors in non-neuronal cells did not lead to cytolytic pore formation.
Neg (not) Positive_regulation (lead) of Positive_regulation (activation) of P2X7 in neuronal associated with agonist
2) Confidence 0.37 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0.05 Pain Relevance 0.18
These findings indicate that activation of the P2X7 receptor accelerates leukocyte infiltration into brain parenchyma in an IL-1?
Positive_regulation (accelerates) of Positive_regulation (activation) of P2X7 in parenchyma
3) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.03 Pain Relevance 0.06
Activation of P2X3, P2X2/3, P2X4, P2X7, and P2Y (e.g.
Positive_regulation (e.g.) of Positive_regulation (Activation) of P2X7
4) Confidence 0.25 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.59 Pain Relevance 0.49
Thus, it is suggested that an activation of P2X7 by ATP induces permitting movement of K+, Na+ and Ca2+ through the cell membrane and provokes the release of IL-1?
Positive_regulation (induces) of Positive_regulation (activation) of P2X7
5) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.17 Pain Relevance 0.35

General Comments

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