INT23787

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Context Info
Confidence 0.68
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 42
Disease Relevance 23.54
Pain Relevance 19.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
microglia 4
parenchyma 2
dorsal horn 2
neuronal 2
neurons 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 52 100.00 Very High Very High Very High
agonist 98 99.98 Very High Very High Very High
Neuropathic pain 298 99.84 Very High Very High Very High
Pain 245 99.84 Very High Very High Very High
Inflammation 240 99.84 Very High Very High Very High
Glutamate 205 99.74 Very High Very High Very High
Dopamine 63 99.68 Very High Very High Very High
antagonist 454 99.58 Very High Very High Very High
Sciatic nerve 33 99.40 Very High Very High Very High
dorsal root ganglion 26 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 558 99.84 Very High Very High Very High
Pain 303 99.84 Very High Very High Very High
INFLAMMATION 258 99.84 Very High Very High Very High
Injury 115 99.72 Very High Very High Very High
Brain Injury 23 99.72 Very High Very High Very High
Ganglion Cysts 27 99.40 Very High Very High Very High
Nociception 56 99.08 Very High Very High Very High
Cv Unclassified Under Development 38 98.96 Very High Very High Very High
Death 80 98.88 Very High Very High Very High
Hypoxia 35 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data from gene knockout studies and recently described selective antagonists indicate a role for P2X7 receptor activation in inflammation and pain.
Positive_regulation (activation) of P2X7 associated with targeted disruption, pain, inflammation and antagonist
1) Confidence 0.68 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.39 Pain Relevance 0.50
Activation of P2X7 receptors leads to rapid changes in intracellular calcium concentrations, release of the pro-inflammatory cytokine IL-1beta, and following prolonged agonist exposure, the formation of cytolytic pores in plasma membranes.
Positive_regulation (Activation) of P2X7 in plasma associated with inflammation, agonist and cytokine
2) Confidence 0.68 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.32 Pain Relevance 0.39
The pharmacological profile for P2X antagonists to inhibit [3H]A-804598 binding correlated with their ability to block functional activation of P2X7 receptors (r=0.95, P<0.05).
Positive_regulation (activation) of P2X7 associated with antagonist
3) Confidence 0.68 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.25 Pain Relevance 0.50
We report that there is an up-regulation of substance P receptor immunoreactivity in the superficial laminae of the dorsal horn in both injury models.
Positive_regulation (up-regulation) of P receptor in dorsal horn associated with injury, dorsal horn and substance p
4) Confidence 0.68 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848125 Disease Relevance 0.83 Pain Relevance 1.14
The increase in substance P receptor immunoreactivity was not only present in the medial part of the dorsal horn at segment L4, which is the region of input of the afferents from the hindpaw, but also in the lateral parts of the dorsal horn, and at segments rostral (L1) and caudal (S1) to the afferent input from the hindpaw.
Positive_regulation (increase) of P receptor in medial associated with dorsal horn and substance p
5) Confidence 0.68 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848125 Disease Relevance 0.79 Pain Relevance 1.30
Furthermore, the non-topographic up-regulation of substance P receptor in these different conditions may contribute to the central sensitization of dorsal horn nociceptors under conditions of persistent pain.
Positive_regulation (up-regulation) of P receptor in dorsal horn associated with pain, central sensitization, lasting pain, nociceptor, dorsal horn and substance p
6) Confidence 0.68 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848125 Disease Relevance 0.70 Pain Relevance 1.19
Further electrophysiological studies showed that prolonged agonist activation of P2X7 receptors in non-neuronal cells did not lead to cytolytic pore formation.
Positive_regulation (activation) of P2X7 in neuronal associated with agonist
7) Confidence 0.51 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0.05 Pain Relevance 0.18
A variable presence of P2X7 receptors on cutaneous sensory nerves with respect to the different treatments was observed.
Positive_regulation (presence) of P2X7 in sensory nerves
8) Confidence 0.48 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0.12 Pain Relevance 0
Receptor autoradiography showed the discrete localization of substance P binding sites in both sensory and motor regions of the spinal cord and functional studies suggested an important role for substance P receptor activation in autonomic outflow, nociception, respiration and somatic motor function.
Positive_regulation (activation) of P receptor in autonomic associated with nociception, spinal cord and substance p
9) Confidence 0.44 Published 1986 Journal Neuroscience Section Abstract Doc Link 2430231 Disease Relevance 0.36 Pain Relevance 0.51
These findings indicate that P2X7 receptor activation may play an important role in neutrophil infiltration into the FPC after SE.


Positive_regulation (activation) of P2X7 in neutrophil associated with status epilepticus
10) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.56 Pain Relevance 0
These findings indicate that P2X7 receptor activation may also play a role in monocyte infiltration into the FPC after SE.


Positive_regulation (activation) of P2X7 in monocyte associated with status epilepticus
11) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.95 Pain Relevance 0
These findings indicate that activation of the P2X7 receptor accelerates leukocyte infiltration into brain parenchyma in an IL-1?
Positive_regulation (activation) of P2X7 in parenchyma
12) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.03 Pain Relevance 0.06
Activation of P2X3, P2X2/3, P2X4, P2X7, and P2Y (e.g.
Positive_regulation (Activation) of P2X7
13) Confidence 0.35 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.59 Pain Relevance 0.48
In addition, a recent study has shown that activation of P2X7 receptors expressed on satellite glia that enwrap each DRG neuron leads to a release of TNF-?
Positive_regulation (activation) of P2X7 in neuron associated with dorsal root ganglion
14) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.35 Pain Relevance 0.82
P2X4R or P2X7R activation leads to the release of bioactive diffusible factors such as BDNF and other proinflammatory factors (cytokines and chemokines).
Positive_regulation (activation) of P2X7R associated with chemokine and cytokine
15) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.69 Pain Relevance 0.73
P2X7 receptors are upregulated in surrounding satellite glial cells in the DRG in humans [12].
Positive_regulation (upregulated) of P2X7 in satellite glial cells associated with dorsal root ganglion
16) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.35 Pain Relevance 0.76
CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo.


Positive_regulation (activating) of P receptor
17) Confidence 0.27 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18798491 Disease Relevance 0 Pain Relevance 0
Therefore, it is obvious that P2X7 receptor activation may accelerate monocyte infiltration in the brain parenchyma following SE.
Positive_regulation (activation) of P2X7 in parenchyma associated with status epilepticus
18) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.30 Pain Relevance 0.07
The P2X7 receptor, an ATP-ligand channel, has attracted much attention as a modulator of inflammatory pathways in the brain, since the P2X7 receptor is upregulated after acute brain injury and in chronic neurological diseases [31-34], and releases cytokines/chemokines from neuroglia [35-37].
Positive_regulation (upregulated) of P2X7 in neuroglia associated with chemokine, neurological disease, inflammation, brain injury and cytokine
19) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.16 Pain Relevance 0.55
These findings indicate that P2X7 receptor activation may accelerate up-regulation of MCP-1 and MIP-2 expression in the FPC, resulting in leukocyte infiltration.


Positive_regulation (activation) of P2X7 in leukocyte
20) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.93 Pain Relevance 0.04

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