INT2379

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 23
Speculated 17
Reported most in Abstract
Documents 349
Total Number 367
Disease Relevance 27.86
Pain Relevance 144.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 38
pituitary 30
anterior pituitary 20
HPOA 18
gonadal 17
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1236 100.00 Very High Very High Very High
cytokine 367 100.00 Very High Very High Very High
Opioid 250 100.00 Very High Very High Very High
opiate 225 100.00 Very High Very High Very High
Nicotine 41 100.00 Very High Very High Very High
excitatory amino acid 39 100.00 Very High Very High Very High
antagonist 911 99.98 Very High Very High Very High
agonist 597 99.98 Very High Very High Very High
Morphine 243 99.98 Very High Very High Very High
Clonidine 95 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Galactorrhea 55 100.00 Very High Very High Very High
Aids-related Complex 31 100.00 Very High Very High Very High
Urological Neuroanatomy 30 100.00 Very High Very High Very High
Hypoglycemia 28 100.00 Very High Very High Very High
Stress 1471 99.98 Very High Very High Very High
Depression 35 99.58 Very High Very High Very High
Nociception 19 99.30 Very High Very High Very High
INFLAMMATION 504 97.48 Very High Very High Very High
Endometriosis (extended) 175 96.48 Very High Very High Very High
Body Weight 97 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute injections of either nalmefene or naloxone (2 mg/kg) produced 4-fold increases in LH and testosterone secretion.
Positive_regulation (increases) of Localization (secretion) of LH associated with narcan
1) Confidence 0.70 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.58
Similarly, progesterone co-administration to ovariectomized, oestradiol-primed rats significantly advanced and augmented LH hypersecretion.
Positive_regulation (augmented) of Localization (hypersecretion) of LH
2) Confidence 0.70 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.12
Supplementation with low doses of oestradiol was itself ineffective in facilitating a spontaneous rise in LH concentration, but nalmefene co-administration significantly potentiated the ability of low doses of oestradiol to induce augmented LH secretion, in addition to advancing the timing of the spontaneous LH rise.
Positive_regulation (augmented) of Localization (secretion) of LH
3) Confidence 0.70 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.11
Hence, the inhibitory effect of naltrexone on LH release appeared to result from an alteration of the central mechanism responsible for EB-induced LH secretion.
Positive_regulation (induced) of Localization (secretion) of LH
4) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.68
These results suggest a possible involvement of endogenous opioid peptides in the neuroendocrine brain differentiation that results in LH release after EB treatment during the prepubertal period in rats.
Positive_regulation (results) of Localization (release) of LH in brain associated with endogenous opioid
5) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.60
The release of LH during the prepubertal period was increased following EB treatment both in intact females and gonadectomized males and females, but not in intact male rats.
Positive_regulation (increased) of Localization (release) of LH
6) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.69
Supplementation with low doses of oestradiol was itself ineffective in facilitating a spontaneous rise in LH concentration, but nalmefene co-administration significantly potentiated the ability of low doses of oestradiol to induce augmented LH secretion, in addition to advancing the timing of the spontaneous LH rise.
Positive_regulation (induce) of Localization (secretion) of LH
7) Confidence 0.70 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3339293 Disease Relevance 0 Pain Relevance 0.11
Association of diurnal variations in hypothalamic but not cortical opiate ([3H]-naloxone)-binding sites with the ability of naloxone to induce LH release in the prepubertal female rat.
Positive_regulation (induce) of Localization (release) of LH associated with narcan and opiate
8) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Title Doc Link 3024054 Disease Relevance 0 Pain Relevance 0.61
At 7 days post-surgery naloxone is no longer able to stimulate LH secretion in male or female rats.
Positive_regulation (stimulate) of Localization (secretion) of LH associated with narcan
9) Confidence 0.70 Published 1983 Journal Endocrinology Section Abstract Doc Link 6291922 Disease Relevance 0 Pain Relevance 0.39
Immobilization for 8 hours resulted in a significant initial increase in LH release, followed by a decline toward baseline levels.
Positive_regulation (increase) of Localization (release) of LH
10) Confidence 0.70 Published 1984 Journal Life Sci. Section Abstract Doc Link 6374352 Disease Relevance 0.41 Pain Relevance 0.39
In an acute study nicotine blocked LH secretion induced by the long acting opioid antagonist naltrexone.
Positive_regulation (induced) of Localization (secretion) of LH associated with long acting opioid, antagonist and nicotine
11) Confidence 0.70 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194685 Disease Relevance 0 Pain Relevance 0.68
Implantation of cholesterol, as a control, in various brain areas did not induce any changes in the pattern of pulsatile LH secretion.
Neg (not) Positive_regulation (induce) of Localization (secretion) of LH in brain
12) Confidence 0.70 Published 1985 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 3996684 Disease Relevance 0.16 Pain Relevance 0.11
Despite this, the naloxone pellet only moderately enhanced the initial rate of increase in LH secretion following ovariectomy (day 1) and was ineffective in further augmenting LH secretion at 3 and 7 days after implantation.
Positive_regulation (increase) of Localization (secretion) of LH associated with narcan
13) Confidence 0.70 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6139759 Disease Relevance 0 Pain Relevance 1.11
Despite this, the naloxone pellet only moderately enhanced the initial rate of increase in LH secretion following ovariectomy (day 1) and was ineffective in further augmenting LH secretion at 3 and 7 days after implantation.
Positive_regulation (augmenting) of Localization (secretion) of LH associated with narcan
14) Confidence 0.70 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6139759 Disease Relevance 0 Pain Relevance 1.11
Furthermore, whereas the release of LH induced by intraventricular injection of norepinephrine in intact rats was enhanced by treatment with propranolol, in rats with PM cuts the already enhanced induced release was no further raised by propranolol treatment.
Positive_regulation (induced) of Localization (release) of LH
15) Confidence 0.69 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6813756 Disease Relevance 0 Pain Relevance 0.10
On the other hand, PM cuts did not affect the suppressive action of the alpha-adrenoblocker phenoxybenzamine on the norepinephrine-induced release of LH.
Neg (not) Positive_regulation (induced) of Localization (release) of LH
16) Confidence 0.69 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6813756 Disease Relevance 0 Pain Relevance 0.08
Thus, in animals with PM cuts (1) the release of LH following the injection of norepinephrine into the third ventricle was enhanced and (2) the blocking action of intraventricular injection of isoproterenol on the release of LH was suppressed whereas the facilitatory effect of clonidine was not changed.
Positive_regulation (enhanced) of Localization (release) of LH in third ventricle associated with clonidine
17) Confidence 0.69 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6813756 Disease Relevance 0 Pain Relevance 0.09
In rats exposed to E2 for 3 days, the P-induced LH release was significantly greater than that observed after saline or NAL infusion.
Positive_regulation (induced) of Localization (release) of LH associated with narcan
18) Confidence 0.69 Published 1992 Journal Brain Res. Section Abstract Doc Link 1504826 Disease Relevance 0 Pain Relevance 0.38
When initiated at the time of castration, both T and M treatments prevented the castration-induced hypersecretion of LH.
Positive_regulation (induced) of Localization (hypersecretion) of LH
19) Confidence 0.69 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2982110 Disease Relevance 0.07 Pain Relevance 0.26
The results demonstrate that naloxone can increase the LH secretion in the absence of ovarian hormones, and further that the effect on LH changes depending upon the dose of naloxone and the time after ovariectomy.
Positive_regulation (increase) of Localization (secretion) of LH associated with narcan
20) Confidence 0.69 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2118607 Disease Relevance 0.06 Pain Relevance 0.32

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