INT237902

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.74
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 3
neutrophils 3
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 112 100.00 Very High Very High Very High
agonist 21 99.60 Very High Very High Very High
Inflammation 94 97.56 Very High Very High Very High
Arthritis 112 95.88 Very High Very High Very High
rheumatoid arthritis 18 92.96 High High
Inflammatory response 10 81.40 Quite High
antagonist 4 74.00 Quite High
cva 1 68.32 Quite High
Central nervous system 1 62.32 Quite High
headache 1 58.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 107 97.56 Very High Very High Very High
Sprains And Strains 56 97.36 Very High Very High Very High
Arthritis 118 95.88 Very High Very High Very High
Appetite Loss 90 94.64 High High
Cancer 38 94.28 High High
Inflammatory Bowel Disease 48 94.20 High High
Rheumatoid Arthritis 18 92.96 High High
Colitis 56 92.72 High High
Infection 49 92.44 High High
Disease 104 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].
Regulation (responsible) of Gene_expression (levels) of cytokines in macrophages associated with cytokine
1) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.86 Pain Relevance 0.05
Together, our data provide novel insight regarding differential expression of cytokines, particularly TNF-?
Regulation (regarding) of Gene_expression (expression) of cytokines associated with cytokine
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.76 Pain Relevance 0.38
Together, our data provide novel insight regarding differential expression of cytokines, particularly TNF-?
Regulation (differential) of Gene_expression (expression) of cytokines associated with cytokine
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.75 Pain Relevance 0.38
The enzyme controls production of NO and cytokines by macrophages and migration of macrophages and neutrophils.
Regulation (controls) of Gene_expression (production) of cytokines in neutrophils associated with cytokine
4) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.30 Pain Relevance 0.58
15d-PGJ2 modulates the expression of proinflammatory cytokines.

2.

Regulation (modulates) of Gene_expression (expression) of cytokines associated with cytokine
5) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.39 Pain Relevance 0.18
The enzyme controls production of NO and cytokines by macrophages and migration of macrophages and neutrophils.
Regulation (controls) of in macrophages Gene_expression (production) of cytokines in neutrophils associated with cytokine
6) Confidence 0.00 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.30 Pain Relevance 0.58
The potential mechanism of action of MA is believed to involve stimulation of appetite by both direct and indirect pathways affecting the metabolism and production of catabolic cytokines [24].
Regulation (affecting) of Gene_expression (production) of cytokines associated with cytokine
7) Confidence 0.00 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 1.38 Pain Relevance 0.21

General Comments

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