INT237904

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.52
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
Th17 cells 4
lymphocytes 2
T cells 2
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 121 100.00 Very High Very High Very High
Inflammation 70 100.00 Very High Very High Very High
psoriasis 55 97.56 Very High Very High Very High
agonist 21 95.44 Very High Very High Very High
Etanercept 17 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 72 100.00 Very High Very High Very High
Chlamydia Infection 67 99.44 Very High Very High Very High
Infection 91 98.62 Very High Very High Very High
Psoriasis 68 97.56 Very High Very High Very High
Hypersensitivity 20 96.40 Very High Very High Very High
Disease 103 95.60 Very High Very High Very High
Cold Sores 53 92.68 High High
Keratitis 37 73.64 Quite High
Multiple Organ Failure 1 68.92 Quite High
Recurrence 2 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
concentrations were reduced in splenocytes isolated from pBTLA treated mice when stimulated in vitro, indicating that pBTLA treated mice had a reduced Th1 immune response.
Negative_regulation (reduced) of Localization (response) of Th1
1) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.31 Pain Relevance 0.13
These results indicate that C. muridarum infection invoked splenic, but not ILNs, Chlamydia-specific CD4+ T cells that secreted Th1 cytokines as well as IL-6, IL-10, and GM-CSF, which were reduced by CCL5 blockade.
Negative_regulation (reduced) of Localization (secreted) of Th1 in T cells associated with chlamydia infection, infection and cytokine
2) Confidence 0.16 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.52 Pain Relevance 0.15
differentiation of Th1 and Th17 cells, which may limit
Negative_regulation (limit) of Localization (differentiation) of Th1 in Th17 cells
3) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.71 Pain Relevance 0.34
One of the plausible mechanisms put forward is immune deviation toward T-helper lymphocytes type 2 (Th2) cytokine characterized by secretion of IL-4, IL-5, IL-10 cytokines with reduced secretion of T-helper lymphocytes type 1 (Th1) cytokines namely IL-2, IL-12, and IFN-.[515–17]
Negative_regulation (reduced) of Localization (secretion) of Th1 in lymphocytes associated with cytokine
4) Confidence 0.09 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.45 Pain Relevance 0.21
Subsequently, both Th1 and Th17 cells and their pro-inflammatory cytokines are reduced resulting in marked efficacy and safety in the treatment of psoriasis.37

Efficacy studies

Negative_regulation (reduced) of Localization (pro) of Th1 in Th17 cells associated with psoriasis, inflammation and cytokine
5) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.53 Pain Relevance 0.25

General Comments

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