INT237907

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.85
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tlr2) plasma membrane (Tlr4, Tlr2) intracellular (Tlr4, Tlr2)
cytoplasm (Tlr4, Tlr2)
Anatomy Link Frequency
spinal cord 3
hepatocytes 2
brain 1
Tlr4 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.12 Very High Very High Very High
Inflammation 93 96.96 Very High Very High Very High
cytokine 53 79.68 Quite High
Inflammatory response 37 73.92 Quite High
alcohol 1 54.00 Quite High
cva 6 51.72 Quite High
agonist 57 50.00 Quite Low
ischemia 12 34.84 Quite Low
Substantia nigra 8 7.12 Low Low
Central nervous system 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 96 98.52 Very High Very High Very High
INFLAMMATION 112 96.96 Very High Very High Very High
Pneumonia 15 95.04 Very High Very High Very High
Disease Progression 10 94.88 High High
Targeted Disruption 41 93.20 High High
Nerve Degeneration 4 85.36 High High
Hepatocellular Cancer 47 84.12 Quite High
Toxicity 11 82.92 Quite High
Liver Cancer 3 80.80 Quite High
Cancer 44 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 expression in hepatocytes is upregulated by LPS, TNF, and others, suggesting that hepatocytes become more sensitive in the inflammatory condition [92].
LPS Positive_regulation (upregulated) of Gene_expression (expression) of TLR2 in hepatocytes associated with inflammation
1) Confidence 0.40 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.97 Pain Relevance 0.14
coculture approaches, have also demonstrated that TLR4 upregulates TLR2 expression in AM?
TLR4 Positive_regulation (upregulates) of Gene_expression (expression) of TLR2
2) Confidence 0.28 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.65 Pain Relevance 0.11
The amplified TLR4-induced TLR2 expression in AM?
TLR4 Positive_regulation (induced) of Gene_expression (expression) of TLR2
3) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.67 Pain Relevance 0.13
The functional relevance of NADPH oxidase in mediating TLR4-induced TLR2 expression in ECs was evident by markedly elevated and stable ICAM-1 expression as well as augmented PMN migration in response to sequential challenge with LPS and PGN (Figure 4) [28].
TLR4 Positive_regulation (induced) of Gene_expression (expression) of TLR2
4) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.45 Pain Relevance 0.03
They injected systemic LPS, which increased TLR2 expression across the brain and spinal cord in both wild-type and mSOD1 mice, without changing mSOD expression.
LPS Positive_regulation (increased) of Gene_expression (expression) of TLR2 in spinal cord associated with spinal cord
5) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.26 Pain Relevance 0.05
induce the expression of TLR4, but does induce the expression of TLR2 [34].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of TLR2
6) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.58 Pain Relevance 0.10
They injected systemic LPS, which increased TLR2 expression across the brain and spinal cord in both wild-type and mSOD1 mice, without changing mSOD expression.
LPS Positive_regulation (increased) of in brain Gene_expression (expression) of TLR2 in spinal cord associated with spinal cord
7) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.26 Pain Relevance 0.05

General Comments

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