INT237927

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.22
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2, BAX) endoplasmic reticulum (BCL2, BAX) cytoplasm (BCL2, BAX)
cytosol (BCL2, BAX) nucleus (BCL2, BAX) cell morphogenesis (BCL2)
Anatomy Link Frequency
cleavage 1
BCL2 (Homo sapiens)
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 28 82.20 Quite High
antagonist 23 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 174 98.92 Very High Very High Very High
Reprotox - General 3 1 97.60 Very High Very High Very High
Parkinson's Disease 2 97.04 Very High Very High Very High
Breast Cancer 7 93.60 High High
Cancer 80 89.08 High High
Colon Cancer 12 85.28 High High
Death 30 79.88 Quite High
Pancreatic Cancer 21 78.20 Quite High
Toxicity 3 77.56 Quite High
Glioma 2 32.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Bcl-2 or induction of Bax breaks the balance between two genes (as showed in Fig.5B), resulting in mitochondrial dysfunction and cytochrome-c release [21,22].
Bcl-2 Positive_regulation (induction) of Bax associated with parkinson's disease
1) Confidence 0.24 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.81 Pain Relevance 0
Bcl-2 and upregulated Bax and Fas while enhancing PARP cleavage and caspase-8
Bcl-2 Positive_regulation (upregulated) of Bax in cleavage
2) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.41 Pain Relevance 0.26

General Comments

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