INT237960

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.27
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
Macrophages 2
colon 2
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 93.72 High High
agonist 30 76.40 Quite High
COX-2 inhibitor 54 73.16 Quite High
antagonist 29 58.36 Quite High
diclofenac 1 40.76 Quite Low
Bile 1 26.96 Quite Low
Inflammation 35 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 78 99.66 Very High Very High Very High
Apoptosis 362 99.24 Very High Very High Very High
Cancer 317 95.00 High High
Death 65 93.44 High High
Renal Cancer 2 93.36 High High
Shock 3 71.20 Quite High
Reprotox - General 1 4 69.08 Quite High
Leukemia 15 67.84 Quite High
Hepatocellular Cancer 4 66.00 Quite High
Glioblastoma 1 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein or DR5 siRNA attenuated rosiglitazone and TRAIL-induced apoptosis,
Negative_regulation (attenuated) of Gene_expression (rosiglitazone) of DR5 associated with apoptosis
1) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.10 Pain Relevance 0.07
Macrophages did not inhibit the expression of DR4 or DR5, or modulate the levels of decoy receptors DcR1 or DcR2 in HCT116/Hke-3 cells (Figure S1), suggesting that they do not modulate the responsiveness to TRAIL through regulation of TRAIL receptors.
Negative_regulation (inhibit) of Gene_expression (expression) of DR5 in Macrophages
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.84 Pain Relevance 0.05
Tang et al. [120] showed that COX-2 overexpression in human colon cancers cells led to an inhibition of DR5 expression and a resistance to TRAIL-induced apoptosis.
Negative_regulation (inhibition) of Gene_expression (expression) of DR5 in colon associated with colon cancer and apoptosis
3) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.32 Pain Relevance 0.07

General Comments

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