INT237973

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCND3) nucleus (CCND3) cell division (CCND3)
cytoplasm (CCND3)
CCND3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 28 16.08 Low Low
antagonist 25 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 25 99.88 Very High Very High Very High
Apoptosis 149 96.84 Very High Very High Very High
Death 32 95.76 Very High Very High Very High
Glioma 28 92.24 High High
Hyperplasia 2 83.56 Quite High
Cancer 125 83.24 Quite High
Breast Cancer 9 82.08 Quite High
Toxicity 3 78.32 Quite High
Colon Cancer 13 62.16 Quite High
Neuroblastoma 1 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, they found that troglitazone decreased cyclin D3 levels through
Negative_regulation (decreased) of cyclin D3
1) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.27 Pain Relevance 0
Reduction of eIF4E resulted in a 89% loss of expression and, full knock-out simulations predicted a complete loss of cyclin D and PSA.


Negative_regulation (loss) of cyclin D associated with targeted disruption
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.48 Pain Relevance 0
ERK knock-ins approximately doubled cyclin D while ERK knock-outs reduced cyclin D to less then one third of wild-type levels.
Negative_regulation (reduced) of cyclin D associated with targeted disruption
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.57 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Negative_regulation (downregulation) of D-type cyclin
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.62 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox