INT238008

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Myd88, Hand1) cell differentiation (Hand1) nucleoplasm (Hand1)
intracellular (Myd88) enzyme binding (Hand1) DNA binding (Hand1)
Myd88 (Mus musculus)
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 77.24 Quite High
agonist 1 27.28 Quite Low
Crohn's disease 25 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 69 98.22 Very High Very High Very High
Paratuberculosis 20 94.96 High High
Mycobacterial Infection 1 85.24 High High
Infection 3 84.48 Quite High
Inflammatory Bowel Disease 19 48.32 Quite Low
Disease 39 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Alagille Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is plausible that Mycobacteria stimulate TLRs to promote colitis in IL-10-/- mice, which presents a scenario where mycobacterial recognition via TLR and MyD88 activate DCs to control Th1 polarization and expansion.
MyD88 Regulation (control) of Th1 associated with colitis
1) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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