INT238009

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.01
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9) signal transduction (Cxcr3) plasma membrane (Cxcr3)
signal transducer activity (Cxcr3)
Cxcr3 (Mus musculus)
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 110 99.68 Very High Very High Very High
cytokine 28 99.68 Very High Very High Very High
Inflammation 38 99.28 Very High Very High Very High
Crohn's disease 26 97.00 Very High Very High Very High
Inflammatory response 3 79.56 Quite High
Lasting pain 1 75.60 Quite High
interstitial cystitis 41 59.72 Quite High
pain pelvic 1 40.40 Quite Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 70 99.40 Very High Very High Very High
INFLAMMATION 40 99.28 Very High Very High Very High
Disease 64 97.00 Very High Very High Very High
Bacillus Anthracis Infection 26 95.88 Very High Very High Very High
Colitis 71 94.48 High High
Toxemia 10 84.80 Quite High
Infection 63 84.40 Quite High
Alagille Syndrome 2 84.16 Quite High
Paratuberculosis 20 78.44 Quite High
Pain 2 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, CXCL9, CXCL10, and CXCL11 bind to a common receptor, CXCR3.
CXCR3 Binding (bind) of CXCL9
1) Confidence 0.40 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.70 Pain Relevance 0.61
CXCR3 interactions with CXCL9, CXCL10 and CXCL11 are important for the selective homing of Th1 effectors cells [10], which mediate mucosal immunity, inflammation, and colitis [11,12].
CXCR3 Binding (interactions) of CXCL9 associated with colitis and inflammation
2) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.85 Pain Relevance 0.51
These results demonstrate the ability of the interferon-inducible ELR- CXC chemokines, in particular CXCL9, to contribute directly to host defense through activities not associated with CXCR3.
CXCR3 Binding (associated) of CXCL9 associated with chemokine
3) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.47 Pain Relevance 0.25

General Comments

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