INT238013

Context Info Confidence 0.42 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.64 Pain Relevance 0.08

extracellular region (MLN) cell-cell signaling (MLN)

Anatomy Link Frequency colon 2 MLN (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 25 87.32 Inflammation 10 76.04 cytokine 12 36.20 chemokine 4 5.00 agonist 3 5.00 Pain 2 5.00 behavioral therapy 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Disease 40 87.32 INFLAMMATION 8 76.04 Colitis 69 69.48 Constipation 13 55.60 Fecal Incontinence 3 55.56 Functional Bowel Disorder 2 54.52 Gastrointestinal Disease 1 50.00 Inflammatory Bowel Disease 19 41.96 Paratuberculosis 20 5.00 Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that the colon motilin receptors may have reduced affinity for erythromycin compared to the antral nerves or the expression of motilin receptor may be reduced in the colon.

Negative_regulation (reduced) of Gene_expression (expression) of motilin in colon

1) Confidence 0.42 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.17 Pain Relevance 0

In the present study, we show that CXCL9 and CXCL11 are predominantly produced by DCs in the MLN as well as in PP and to a lesser degree in the intestinal LP.

Negative_regulation (degree) of Gene_expression (produced) of MLN

2) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

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