INT238038

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.45
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
spine 3
OPLL 1
posterior 1
BMP2 (Homo sapiens)
OPLL (Homo sapiens)
BMP2 - S37A (1)
Pain Link Frequency Relevance Heat
Osteoarthritis 8 80.04 Quite High
antagonist 24 54.36 Quite High
agonist 16 49.08 Quite Low
spinal inflammation 16 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 16 100.00 Very High Very High Very High
Osteoporosis 64 97.52 Very High Very High Very High
Heterotopic Ossification 120 96.20 Very High Very High Very High
Disease 56 87.20 High High
Metabolic Disorder 24 87.16 High High
Osteoarthritis 8 80.04 Quite High
Rickets 16 5.00 Very Low Very Low Very Low
Low Back Pain 16 5.00 Very Low Very Low Very Low
Spinal Cord Diseases 16 5.00 Very Low Very Low Very Low
Hypercalcemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present studies show that the Ser87Ser (A/G) polymorphism in the BMP-2 gene is associated with more extensive OPLL, but not with its occurrence rate in the cervical spine.
BMP-2 gene Binding (associated) of OPLL in spine
1) Confidence 0.20 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.35 Pain Relevance 0
In conclusion, the present results demonstrate that the polymorphisms in the BMP-2 gene are not only a factor associated with the occurrence of OPLL, but also a factor related to more extensive OPLL.
BMP-2 gene Binding (associated) of OPLL
2) Confidence 0.16 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.16 Pain Relevance 0.05
The purpose of this study was to investigate association of two SNPs of BMP-2 gene with susceptibility to OPLL of the spine and its severity in Chinese patients.
BMP-2 gene Binding (association) of OPLL in spine
3) Confidence 0.16 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.88 Pain Relevance 0.04
The current studies show that the Ser37Ala (T/G) polymorphism in exon 2 of BMP-2 gene is associated with the occurrence of OPLL, but not with more extensive OPLL in the cervical spine.
BMP-2 gene Binding (associated) of OPLL in spine
4) Confidence 0.16 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.28 Pain Relevance 0
The present results demonstrate that BMP-2 Gene is not only a factor associated with the occurrence of OPLL, but also a factor related to more extensive OPLL.
BMP-2 Gene Binding (associated) of OPLL
5) Confidence 0.15 Published 2008 Journal Eur Spine J Section Abstract Doc Link PMC2443260 Disease Relevance 0.12 Pain Relevance 0
The present results demonstrate that BMP-2 Gene is not only a factor associated with the occurrence of OPLL, but also a factor related to more extensive OPLL.
BMP-2 Gene Binding (associated) of OPLL
6) Confidence 0.15 Published 2008 Journal Eur Spine J Section Abstract Doc Link PMC2443260 Disease Relevance 0.12 Pain Relevance 0
Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients

A caseĀ–control study was conducted to examine the association between two single nucleotide polymorphisms (SNPs) in exon 2 of the bone morphogenetic protein-2 gene (BMP-2) and ossification of the posterior longitudinal ligament (OPLL), and to investigate whether SNPs of the Ser37Ala (T/G) and the Ser87Ser (A/G) in the BMP-2 gene are associated with genetic susceptibility to OPLL and its severity in Chinese subjects.

BMP-2 gene (S37A) Binding (associated) of OPLL in OPLL associated with genetic predisposition to disease
7) Confidence 0.15 Published 2008 Journal Eur Spine J Section Title Doc Link PMC2443260 Disease Relevance 0.28 Pain Relevance 0
Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients

A caseĀ–control study was conducted to examine the association between two single nucleotide polymorphisms (SNPs) in exon 2 of the bone morphogenetic protein-2 gene (BMP-2) and ossification of the posterior longitudinal ligament (OPLL), and to investigate whether SNPs of the Ser37Ala (T/G) and the Ser87Ser (A/G) in the BMP-2 gene are associated with genetic susceptibility to OPLL and its severity in Chinese subjects.

bone morphogenetic protein-2 gene Spec (examine) Binding (association) of OPLL in posterior associated with genetic predisposition to disease
8) Confidence 0.15 Published 2008 Journal Eur Spine J Section Title Doc Link PMC2443260 Disease Relevance 0.26 Pain Relevance 0

General Comments

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