INT238041

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.95
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spine 1
OPLL (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 12 99.52 Very High Very High Very High
imagery 6 80.44 Quite High
Spinal cord 20 77.92 Quite High
Osteoarthritis 6 75.36 Quite High
Pain 23 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Facet joint 3 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
epidural 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 18 99.98 Very High Very High Very High
Low Back Pain 15 99.52 Very High Very High Very High
Pathologic Constriction 10 99.16 Very High Very High Very High
Rickets 12 99.08 Very High Very High Very High
Diffuse Idiopathic Skeletal Hyperostosis 6 98.20 Very High Very High Very High
Hypercalcemia 6 96.08 Very High Very High Very High
Disease 43 95.44 Very High Very High Very High
Osteoporosis 48 92.84 High High
Spinal Cord Diseases 29 79.64 Quite High
Kyphosis 15 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association between two SNPs of BMP-2 gene and OPLL is firstly reported in the paper.


OPLL Binding (Association) of
1) Confidence 0.27 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.85 Pain Relevance 0.04
The most common reason for excluding a patient from the study was ankylosing spondylitis and metabolic diseases associated with OPLL.
OPLL Binding (associated) of associated with spinal inflammation and metabolic disorder
2) Confidence 0.24 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.72 Pain Relevance 0.22
29) SNP is most significantly associated with OPLL [28].
OPLL Binding (associated) of
3) Confidence 0.18 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.12 Pain Relevance 0.03
A substitution, is significantly associated with OPLL, and the functional variant results in altered splicing, which is protective in the pathogenesis of OPLL [10].
OPLL Binding (associated) of
4) Confidence 0.18 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.15 Pain Relevance 0.04
The patients with ankylosing spondylitis and metabolic diseases associated with OPLL such as hypophosphate rickets/osteomalacia, diffuse idiopathic skeletal hyperostosis (DISH), and hyperparathyroidism were excluded according to radiographic and biochemical examinations.
OPLL Binding (associated) of associated with spinal inflammation, metabolic disorder, rickets, hypercalcemia and diffuse idiopathic skeletal hyperostosis
5) Confidence 0.18 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.74 Pain Relevance 0.21
The “G” allele in the Ser37Ala (T/G) polymorphism is associated with the occurrence of OPLL, but not more extensive OPLL in the cervical spine.
OPLL Binding (associated) of in spine
6) Confidence 0.18 Published 2008 Journal Eur Spine J Section Abstract Doc Link PMC2443260 Disease Relevance 0.10 Pain Relevance 0
For example, if such a patient has a large mass of OPLL arising at C3, with stenosis distal to C3 but not involving C2-3, one might still consider decompressing C2 prophylactically.
OPLL Neg (not) Spec (might) Binding (mass) of associated with pathologic constriction
7) Confidence 0.05 Published 2008 Journal Asian Spine Journal Section Body Doc Link PMC2852088 Disease Relevance 0.26 Pain Relevance 0

General Comments

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