INT238049

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.06
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
posterior 4
ligaments 2
skin 2
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 12 100.00 Very High Very High Very High
agonist 8 89.76 High High
antagonist 13 88.72 High High
metalloproteinase 5 75.44 Quite High
cytokine 9 55.20 Quite High
Facet joint 19 5.00 Very Low Very Low Very Low
imagery 17 5.00 Very Low Very Low Very Low
spinal inflammation 9 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 4 99.56 Very High Very High Very High
Heterotopic Ossification 147 94.72 High High
Respiratory Failure 1 94.60 High High
Atherosclerosis 1 93.60 High High
Calcification 4 91.68 High High
Targeted Disruption 12 90.32 High High
Hematological Disease 1 88.84 High High
Disease 34 87.28 High High
Intervertebral Disk Degeneration 34 83.28 Quite High
Spinal Cord Diseases 8 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most likely explanation for this is two SNPs variations may yield the alternative transcript and translation with abnormal function and further cause the overexpression of BMP-2 protein in the posterior longitudinal ligament matrix.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP-2 protein in posterior
1) Confidence 0.51 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.09 Pain Relevance 0.09
The overexpression of BMP-2 protein in the posterior longitudinal ligament matrix can augment the signaling activity of endogenously produced BMPs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP-2 protein in posterior
2) Confidence 0.51 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.06 Pain Relevance 0.20
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of Gene_expression (expression) of BMP-2
3) Confidence 0.43 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
In fact, while frontal skin showed significant overexpression of BDNF, BMP2, L1-CAM, Meteorin and NR-CAM and significant underexpression of Midkine respect to the velvet, significant gene expression differences between pedicle skin and velvet were restricted to FGF2 and NR-CAM.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BMP2 in skin associated with bdmf
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.14
Collectively, augmented BMP-2 signal via the high expression of BMPRS and ActRs in the ectopic ossified ligaments suggests that BMP-2 protein is more active and may be tightly involved in the pathological ossification process of OPLL.
Positive_regulation (augmented) of Gene_expression (expression) of BMP-2 in ligaments associated with heterotopic ossification
5) Confidence 0.37 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.09 Pain Relevance 0.10
The histopathologic features of OPLL are characterized by the abnormal expression of BMP-2, TGF-?
Positive_regulation (abnormal) of Gene_expression (expression) of BMP-2
6) Confidence 0.37 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.32 Pain Relevance 0
Overexpression of BMP2 under the human ?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of BMP2
7) Confidence 0.22 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.18 Pain Relevance 0
The mechanism of this interplay between HSCs and MSCs is believed to follow the expression of bone morphogenetic protein 2 (BMP-2) and BMP-6.
Positive_regulation (follow) of Gene_expression (expression) of BMP-2
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597748 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

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