INT238058

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
epithelium 1
Shbdp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 99.56 Very High Very High Very High
nMDA receptor 42 94.92 High High
antagonist 27 88.52 High High
metalloproteinase 17 79.84 Quite High
lidocaine 6 75.44 Quite High
Potency 4 62.16 Quite High
addiction 4 52.64 Quite High
agonist 7 14.88 Low Low
TRP channel 2 13.36 Low Low
Spinal cord 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 9 97.76 Very High Very High Very High
Syndrome 70 95.36 Very High Very High Very High
Loss Of Sense Of Smell 30 88.72 High High
Death 8 83.68 Quite High
Disease 8 68.32 Quite High
Keloid Scars 1 63.24 Quite High
Corneal Opacity 1 61.44 Quite High
Ventricular Heart Septal Defects 3 56.28 Quite High
Congenital Anomalies 23 48.88 Quite Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is fascinating that the diverse and severe pathology observed in this study is caused by only a 25–35% decrease in the level of Nipbl transcripts (Figure 5; also see Table S2 and Table S3).
Negative_regulation (decrease) of S2
1) Confidence 0.10 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.88 Pain Relevance 0
Looking at Figure 8C, SKF96365 can be hypothesized to lock the S2 and S3 domains into a fixed position, thereby preventing conformational shifts of the S4 domain induced by menthol (or cooling) that would lead to channel activation.
Negative_regulation (lock) of S2
2) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.17
In fact, histological analysis of the mouse MOE about two months after Zicam treatment showed complete or near-complete loss of the epithelium and submucosa (Figure S2).
Negative_regulation (loss) of S2 in epithelium
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765727 Disease Relevance 0.48 Pain Relevance 0.08
As described already for hippocampal neurons [15], PMA-mediated activation of protein kinase C (PKC) induced a fast reduction of the number of S2 and C2-specific clusters also in spinal neurons.
Negative_regulation (reduction) of S2 in neurons associated with kinase c
4) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.17

General Comments

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