INT238158

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.69
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sik1) cytosol (Sik1) nucleus (Sik1)
cell cycle (Sik1) kinase activity (Sik1) cytoplasm (Sik1)
Anatomy Link Frequency
myocardium 1
nucleus 1
Sik1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 65.68 Quite High
addiction 5 29.80 Quite Low
anesthesia 10 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Acupuncture 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 30 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Squamous Cell Neoplasms 5 98.72 Very High Very High Very High
Coronary Heart Disease 35 89.00 High High
Adhesions 40 25.52 Quite Low
Apoptosis 10 23.16 Low Low
Hyperplasia 5 15.24 Low Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
Phosphorylation (hyperphosphorylation) of MSK-bound in myocardium
1) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
In addition, STAT3 was significantly phosphorylated under these conditions in both detergent soluble and insoluble (CSK and MSK) fractions, and the level of P-STAT3 was increased in both nuclear and cytoplasmic fractions.
Phosphorylation (phosphorylated) of MSK
2) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.31 Pain Relevance 0
Increased level of P-STAT3 in both the MSK and nucleus indicates a dual role of STAT3 in cytoskeletal remodeling and cell survival during PO hypertrophy, a model that has already been implicated in cancer.8 Interestingly, a recent publication9 has shown that STAT3 phosphorylation in multicellular aggregates of squamous cell cancer cell lines begins as a diffuse cytoplasmic distribution and at cell-cell junctions at first with very little nuclear localization, but at later time points (12-24 h), P-STAT3 accumulates in the nucleus.
Phosphorylation (phosphorylation) of MSK in nucleus associated with hypertrophy, squamous cell neoplasms and cancer
3) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.38 Pain Relevance 0.03
However, only pressure-overloaded RV (both Sol and MSK) showed an increase in overall levels, consistent with the RVPO time course (Figure 4a), and a significant migration towards the positive electrode during isoelectric focusing, indicating hyperphosphorylation.
Phosphorylation (hyperphosphorylation) of MSK
4) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
To confirm BMX activation, we explored its phosphorylation state in both detergent soluble and MSK fractions, since autophosphorylation on a specific tyrosine residue in the catalytic domain is critical for its kinase activity.21 We performed two-dimensional (2D) gel electrophoresis (Figure 4c) of soluble and MSK fractions as commercial antibodies were not suitable for immunoprecipitation using feline detergent-insoluble fractions.
Phosphorylation (phosphorylation) of MSK
5) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0

General Comments

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