INT238163

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 0.48
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bmx) cell adhesion (Bmx) kinase activity (Bmx)
cytoplasm (Bmx)
Anatomy Link Frequency
myocardium 5
Bmx (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 10 73.40 Quite High
imagery 10 66.92 Quite High
cytokine 40 66.20 Quite High
Acupuncture 10 56.32 Quite High
anesthesia 20 45.44 Quite Low
fibrosis 10 30.20 Quite Low
Thoracotomy 10 20.56 Low Low
Immobilon 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 70 94.04 High High
Adhesions 80 69.20 Quite High
Reperfusion Injury 10 36.00 Quite Low
Fibrosis 10 30.20 Quite Low
Injury 10 28.04 Quite Low
Targeted Disruption 10 21.88 Low Low
Hypertrophy 60 19.92 Low Low
Apoptosis 20 13.80 Low Low
Cytomegalovirus Infection 20 5.00 Very Low Very Low Very Low
Hyperplasia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, the increased level of BMX in Triton X-100 soluble and insoluble MSK fractions, relative to CSK fraction, correlates well with the increased levels of P-STAT3 in these fractions (Figure 1a).
Positive_regulation (increased) of BMX
1) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.13 Pain Relevance 0
Subsequent activation of BMX can then mediate STAT3 phosphorylation.
Positive_regulation (activation) of BMX
2) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.16 Pain Relevance 0.03
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
Positive_regulation (increase) of BMX in myocardium
3) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
To confirm BMX activation, we explored its phosphorylation state in both detergent soluble and MSK fractions, since autophosphorylation on a specific tyrosine residue in the catalytic domain is critical for its kinase activity.21 We performed two-dimensional (2D) gel electrophoresis (Figure 4c) of soluble and MSK fractions as commercial antibodies were not suitable for immunoprecipitation using feline detergent-insoluble fractions.
Positive_regulation (activation) of BMX
4) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Importantly, a substantial amount of BMX was also recruited to the MSK, similar to STAT3 (Figure 1).
Positive_regulation (amount) of BMX
5) Confidence 0.14 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
Positive_regulation (recruitment) of BMX in myocardium
6) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
Since both STAT3 and BMX exhibit similar redistribution and phosphorylation, these data and our in vivo observations showing a complex formation between BMX and STAT3 in PO myocardium strongly indicate that integrin-mediated BMX activation might serve as an upstream kinase for STAT3 activation in hypertrophying myocardium.
Positive_regulation (activation) of BMX in myocardium
7) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.20 Pain Relevance 0.03
Membrane Skeletal Redistribution and Phosphorylation/activation of BMX in PO Myocardium
Positive_regulation (activation) of BMX in Myocardium
8) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
Our present studies indicate a novel mechanism of activation and redistribution of STAT3 in PO myocardium with the involvement of integrin-mediated BMX activation.


Positive_regulation (activation) of BMX in myocardium
9) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.06
Results shown in Figure 4a demonstrate that BMX levels in 48 h PO RV were markedly increased in the soluble fraction compared to same animal control LV.
Positive_regulation (increased) of BMX
10) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03

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