INT238180

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.99
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
epithelial cells 2
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 15 70.84 Quite High
cytokine 4 30.52 Quite Low
imagery 13 28.72 Quite Low
Mechanosensation 8 5.00 Very Low Very Low Very Low
Somatostatin 8 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Mechanotransduction 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 92 100.00 Very High Very High Very High
Polycystic Kidney Disease 124 93.60 High High
Coronary Artery Disease 4 91.88 High High
Glioma 48 89.80 High High
Lymphatic System Cancer 5 86.56 High High
Cancer 142 72.44 Quite High
Metastasis 62 47.40 Quite Low
Carcinoma 17 46.96 Quite Low
Anaplastic Astrocytoma 1 39.92 Quite Low
Malignant Neoplastic Disease 9 39.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the mechanism of action of hUCBSC, we repeated the experiment with FAK inhibitor and siRNA to FAK (siFAK).
FAK Binding (experiment) of
1) Confidence 0.35 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.72 Pain Relevance 0
In normal epithelial cells, PC-1 is found in a complex with talin (TAL), paxillin (PAX), vinculin (VINC), focal adhesion kinase (FAK), c-src (SRC), p130-cas (CAS), nephrocystin (NPH1) and tensin (TEN).
FAK Binding (complex) of in epithelial cells associated with adhesions
2) Confidence 0.10 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.95 Pain Relevance 0
In contrast, ESb-DKO cells demonstrated only background levels of immunoreactivity for pFAK-Y397.
pFAK-Y397 Binding (immunoreactivity) of
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2689678 Disease Relevance 0.31 Pain Relevance 0.04
In normal epithelial cells, PC-1 is found in a complex with talin (TAL), paxillin (PAX), vinculin (VINC), focal adhesion kinase (FAK), c-src (SRC), p130-cas (CAS), nephrocystin (NPH1) and tensin (TEN).
adhesion kinase Binding (complex) of in epithelial cells associated with adhesions
4) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.95 Pain Relevance 0
Whereas our previous studies show c-Src and FAK recruitment to the CSK fraction, we observe in the present study BMX recruitment to the MSK fraction similar to STAT3.
FAK Binding (recruitment) of
5) Confidence 0.03 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.06 Pain Relevance 0

General Comments

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