INT238201

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.09
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
macrophages 1
uterine 1
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 98.52 Very High Very High Very High
Osteoarthritis 63 91.56 High High
antagonist 2 84.96 Quite High
cva 3 76.32 Quite High
chemokine 4 74.16 Quite High
headache 3 70.48 Quite High
Chronic pancreatitis 9 68.16 Quite High
Inflammation 40 54.52 Quite High
Inflammatory stimuli 2 36.88 Quite Low
Kinase C inhibitor 1 28.72 Quite Low
Disease Link Frequency Relevance Heat
Cancer 132 99.98 Very High Very High Very High
Primary Sclerosing Cholangitis 31 99.84 Very High Very High Very High
Adenocarcinoma 15 99.56 Very High Very High Very High
Leiomyosarcoma 59 99.52 Very High Very High Very High
Infection 68 99.48 Very High Very High Very High
Hepatitis C Virus Infection 117 99.28 Very High Very High Very High
Opiate Addiction 79 99.10 Very High Very High Very High
Lymphoproliferative Disease 1 96.40 Very High Very High Very High
Chronic Myeloid Leukemia 1 95.40 Very High Very High Very High
Generaliased Trisomy 1 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore the role of JAK2 overexpression in PSC of PDAC tumors remains to be functionally elucidated.
Gene_expression (overexpression) of JAK2 associated with adenocarcinoma, cancer and primary sclerosing cholangitis
1) Confidence 0.70 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.16 Pain Relevance 0.10
Kralovics et al. [13] found loss of heterozygosity to be present in chromosome 9p, where JAK2 resides.
Gene_expression (resides) of JAK2
2) Confidence 0.66 Published 2009 Journal Thromb J Section Body Doc Link PMC2652439 Disease Relevance 1.36 Pain Relevance 0.04
No mutations were found in the Von Hippel-Lindau, HIF-1alpha, HIF-2alpha, PHD1, PHD2, PHD3, and JAK2 genes.
Neg (No) Gene_expression (found) of JAK2
3) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.46 Pain Relevance 0.12
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Gene_expression (kinases) of JAK2
4) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.23
Although the genetic approach has already addressed that marked JAK2 activation causes myelo- and lymphoproliferative disease (Baxter et al. 2005; Campbell et al. 2005; James et al. 2005; Kralovics et al. 2005; Tefferi et al. 2005), no somatic mutation in the ATP-binding region and kinase-active site of JAK2 was detected in uterine LMS.
Gene_expression (detected) of JAK2 in uterine associated with leiomyosarcoma and lymphoproliferative disease
5) Confidence 0.36 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.69 Pain Relevance 0
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Gene_expression (expression) of JAK-2 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.33 Pain Relevance 0.05
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Gene_expression (expression) of JAK2 in macrophages
7) Confidence 0.28 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14
An earlier study40 in a murine transverse aortic constriction PO model demonstrates that STAT3 undergoes biphasic acute (3 h) and hypertrophic responses (48 h) via the gp130-mediated JAK2 signaling where the activated STAT3 plays an autoregulatory negative feedback role by promoting the expression of a JAK2 inhibitor protein, SOCS3 (suppressor of cytokine signaling-3).
Gene_expression (expression) of JAK2 associated with cytokine
8) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
Perhaps it is the tumor expression of IL-23, IL-6, epidermal growth factor or Janus kinase 2 or an undefined factor that ultimately regulates the expression of PBMC p-STAT-3 levels, but this was not determined in our current study.
Gene_expression (expression) of Janus kinase 2 associated with cancer
9) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.56 Pain Relevance 0.08

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