INT238207

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.43
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Bmx, Sik1) kinase activity (Bmx, Sik1) cell differentiation (Sik1)
cytosol (Sik1) signal transduction (Bmx) cell adhesion (Bmx)
Anatomy Link Frequency
myocardium 1
Bmx (Mus musculus)
Sik1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 5 80.72 Quite High
addiction 5 60.16 Quite High
cytokine 20 44.60 Quite Low
anesthesia 10 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
Acupuncture 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 40 98.70 Very High Very High Very High
Coronary Heart Disease 35 5.00 Very Low Very Low Very Low
Hypertrophy 30 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Reperfusion Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies on BMX in 48 h PO myocardium include: (i) overall increase of BMX, (ii) recruitment of a significant amount of BMX to the MSK as in the case of STAT3, (iii) hyperphosphorylation of MSK-bound BMX and (iv) the presence of a BMX/STAT3 complex in MSK.
BMX Binding (complex) of MSK in myocardium
1) Confidence 0.01 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Importantly, a substantial amount of BMX was also recruited to the MSK, similar to STAT3 (Figure 1).
BMX Binding (recruited) of MSK
2) Confidence 0.01 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.03
Although our studies3-5 indicate that most focal adhesion proteins are found in the CSK fraction, it is not clear whether BMX and STAT3, which are complexed in the MSK fraction, are part of the focal adhesion or represent an independent localization in the cell.
BMX Binding (complexed) of MSK associated with adhesions
3) Confidence 0.01 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.20 Pain Relevance 0.04
Whereas our previous studies show c-Src and FAK recruitment to the CSK fraction, we observe in the present study BMX recruitment to the MSK fraction similar to STAT3.
BMX Binding (recruitment) of MSK
4) Confidence 0.01 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.12 Pain Relevance 0
Whereas our previous studies show c-Src and FAK recruitment to the CSK fraction, we observe in the present study BMX recruitment to the MSK fraction similar to STAT3.
BMX Binding (recruitment) of MSK
5) Confidence 0.01 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.12 Pain Relevance 0

General Comments

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