INT238259

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (C7, C6) extracellular space (C6) extracellular region (C6)
C7 (Rattus norvegicus)
C6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 92.26 High High
Spinal cord 57 63.24 Quite High
Central nervous system 29 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 57 68.76 Quite High
Spinal Cord Injury 70 63.24 Quite High
Central Nervous System Disease 28 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low
Cicatrix 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggested that cell lysates and supernatant collected from cultured PMNs that were exposed to cytokines or C. albicans hyphae opsonized with normal human serum had elevated levels of C6 and C7 proteins [18,19]; however, it was not conclusive that these proteins were produced by PMNs in culture because (1) the rise in C6 or C7 in culture could have been released by C. albicans hyphae or derived from normal human serum, (2) the inhibition of protein biosynthesis by cycloheximide did not affect the rise in C6 or C7 in PMN cultures [18], and (3) conclusive evidence showing that PMNs are actively expressing these terminal complement mRNAs or proteins has been lacking in the literature.
Neg (not) Regulation (affect) of C7 Negative_regulation (rise) of C6 associated with cytokine
1) Confidence 0.06 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.24 Pain Relevance 0.13

General Comments

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